○ PI3K inhibitor : LY294002, taselisib, alpelisib, MK-2206, idelalisib (CAL-101), dactolisib (BEZ-235), everolimus, pictilisib (GDC-0941), apitolisib (GDC-0980)

○ IκB inhibitor : Bortezomib

○ sPLA2-IIa inhibitor : cFLSYR, c(2NapA)LS(2NapA)R

○ AMPK inhibitor : dorsomorphin

○ Phosphorylation signal transduction inhibitor : lapatinib

○ PARP1/2 inhibitor : olaparib

○ PLK4 inhibitor : CFI400945

○ p38 inhibitor : VX-745

○ CHEK1/2 inhibitor : AZD-7762, AZD7762

○ CHEK1-selective inhibitor : SAR-020106, rabusertib

○ CHEK2-selective inhibitor : CCT-241533

○ JNK inhibitor : JNK-IN-8

○ ATM inhibitor : AZD-1390

○ CCL7 inhibitor : Bindarit

○ MST1R inhibitor : MK-8033

○ TGFβR inhibitor : RepSox

○ DDR1 inhibitor : 7rh

○ Rock1 inhibitor : Y-27632

○ CCR4 inhibitor : C021

○ Hif-1a inhibitor : KC7F2

○ WEE1, PLK1 inhibitor : MK-1775

○ BCL2, BCL-XL, BCL-W inhibitor : navitoclax

○ ATPase inhibitor : NaN3

○ anti-VEGF : ranibizumab, aflibercept, bevacizumab

○ VEGFR tyrosine kinase inhibitor : sunitinib, pazopanib, axitinib, IM2C6, CDP791

○ Tyrosine phosphorylation enzyme inhibitors : imatinib (Glivec), dasatinib (Sprycel), sunitinib (Sutent), nilotinib (Tasigna), sorafenib (Nexavr), temsirolimus (Torisel)

3. Cellular Component

⑴ Endocytosis inhibitors

○ Macropinocytosis inhibitor : EPIA (5-(N-ethyl-N-isopropyl)amiloride)

○ Mannose receptor-mediated endocytosis inhibitor : mannan

○ Clathrin-mediated endocytosis inhibitor : dynasore (dynamin inhibitor), chlorpromazine

○ Caveolar-mediated endocytosis inhibitor : dynasore (dynamin inhibitor), nystatin

○ Endosomal escape inhibitors

○ Nocodazole : Disrupts microtubules to alter endosomal progression

○ Bafilomycin

○ Macrolide antibiotics. Inhibitors of V-type H+ pumps

○ Inhibits endosomal acidification → inhibits transformation of early endosomes to late endosomes and lysosomes

⑵ Macropinocytosis enhancers

○ Small molecule with membrane-destabilizing property : chloroquine, siramesine, amitriptyline

⑶ Metabolic inhibitors

○ GLUT1 inhibitor : bay-876

○ Pfkp inhibitor : PFK15

○ 2-deoxy-D-glucose inhibitor : Gpi1

○ Lipofermata inhibitor : FATP2

○ Atglistatin inhibitor : ATGL

⑷ Mitochondrial Electron Transport Inhibitors

○ Rotenone

○ Barbituric acid

○ Piericidin

○ Malonic acid

○ Antimycin

○ KCN

○ CO

○ Oligomycin

○ DNP

○ Valinomycin

○ Thermogenin

⑸ Cell Division Inhibitors

○ Epothilones

○ Halichondrin B analogue

○ Taxanes

○ Vinca alkaloid

○ Anthracemedione

○ Anthracycline

○ Epipodophyllotoxin

○ Folate antagonist

○ Purine analogue

○ Pyrimidine analogue

○ Hydroxyurea

○ Methotrexate

○ Anthracemedione

○ Anthracycline

○ Epipodophyllotoxin

○ Bleomycin

○ Dactinomycin

○ Mitomycin

○ Alkyl sulfonate

○ Ethylenimine

○ Nitrogen mustard

○ Nitrosurea

○ Platinum analogue

○ Triazene

⑹ Central Dogma-related Inhibitors

○ Acyclovir (acycloguanosine): Antiviral agent. Inhibits viral DNA synthesis by reacting with viral thymidine kinase (tk).

○ AraC (cytosine arabinoside, cytarabine) : Anticancer agent

○ AraA (adenine arabinoside, vidarabine) : Antiviral agent

○ Antinomycin D : Binds to the groove of DNA to prevent replication. Can also affect eukaryotic cells.

○ Fluoroquinolones (ciprofloxacin) : Inhibits DNA gyrase

○ Carboplatin : Anticancer agent that inhibits DNA synthesis

○ Irinotecan : TOP1 inhibitor

○ Topotecan : TOP1 inhibitor

○ Camptothecin : TOP1 inhibitor

○ Diflomotecan : TOP1 inhibitor

○ Lamellarin D : TOP1 inhibitor

○ Etoposide : TOP2 inhibitor

○ Teniposide : TOP2 inhibitor

○ Doxorubicin : TOP2 inhibitor

○ Daunorubicin : TOP2 inhibitor

○ Mitoxantrone : TOP2 inhibitor

○ Amsacrine : TOP2 inhibitor

○ Ellipticines : TOP2 inhibitor

○ Aurintricarboxylic acid : TOP2 inhibitor

○ HU-331 : TOP2 inhibitor

○ Antinomycin D : Transcription inhibitor

○ Cycloheximide : Translation inhibitor in eukaryotic cells

○ Chloramphenicol : Inhibits translation in bacteria

○ Erythromycin : Inhibits translation in bacteria

○ Neomycin : Inhibits translation in bacteria

○ Streptomycin : Inhibits translation in bacteria

○ Tetracycline : Inhibits translation in bacteria

○ AZT (Zidovudine) : Reverse transcriptase inhibitor

○ Combivir (AZT + Epivir) : Reverse transcriptase inhibitor

○ Emtriva (emtricitabine) : Reverse transcriptase inhibitor

○ Epivir (Lamivudine) : Reverse transcriptase inhibitor

○ Epzicom (Abacavir + Epivir) : Reverse transcriptase inhibitor

○ Hivid (ddC) : Reverse transcriptase inhibitor

○ Trizivir (Abacavir + AZT + Epivir) : Reverse transcriptase inhibitor

○ Videx & Videx EC (ddI) : Reverse transcriptase inhibitor

○ Zerit (D4T) : Reverse transcriptase inhibitor

○ Ziagen (Abacavir) : Reverse transcriptase inhibitor

⑺ Cytochrome P450 Inhibitors

○ Cimetidine

○ Ciprofloxacin

○ Disulfiram

○ Erythromycin

○ Fluconazole

○ Fluoxetine

○ Furafylline

○ Isoniazid

○ Ketoconazole

○ Methadone

○ Mibefradil

○ Orphenadrine

○ Paroxetine

○ Quinidine

○ Ritonavir

○ Sulfaphenazole

○ Ticlopidine

○ Tranylcypromine

○ Troglitazone

⑻ Protease

○ Crixsivan : One of the HIV protease inhibitors used for AIDS treatment

○ MG132 : Proteasomal inhibitor

4. Biological Process

⑴ Cholinesterase Inhibitors

○ Aricept® (donepezil)

○ Exelon® (rivastigmine)

○ Razadyne® (galantamine)

○ Reminyl® (galantamine)

⑵ Neuronal Activity Inhibitors

○ Tetrodotoxin : Irreversibly blocks voltage-gated sodium channels in excitable cells

○ Tetraethylammonium : Blocks voltage-gated potassium channels

○ Botox : Blocks voltage-gated calcium ion channels in neuromuscular junctions → Impairs acetylcholine release → Muscle paralysis

○ CPZ : Decreases or inhibits neurotransmitter release

⑶ Blood Coagulation Inhibitors

○ Prostacyclin (PGI2)

○ Nitric oxide (NO)

○ Aspirin

○ Heparin

○ Hirudin

○ EDTA

○ Sodium citrate

○ Sodium oxalate

○ Plasmin

○ Fondaparinux

○ Rivaroxaban

○ Apixaban

○ Dabigatran

○ Bivalirudin

○ Argatroban

○ Clopidogrel

○ Prasugrel

○ Ticagrelor

○ Tirofiban

○ HBA(hydroxybenzy alcohol)

⑷ Immunosuppressants

○ Cyclosporin

⑸ Vascular Action Inhibitors

○ Thrombospondin-1 : Inhibitor of vascular neogenesis. Binds to CD36.

⑹ Lymphatic marker

○ LYVE1

⑺ Monitoring marker for chronic hepatitis

○ HCV-RNA level

Input: 2021.10.07 11:53

Modified: 2022.09.03 17:39

311

Drug Class Library

1. Overview

2. Molecular Function

3. Cellular Component

4. Biological Process

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