Chapter 1-2. Biopolymer Library
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1. Overview
1. Overview
⑴ AlphaFold2 was selected as the Method of the Year in 2021 and awarded the Nobel Prize in Chemistry in 2024 → AlphaFold2 is used as the standard for protein models inserted into the blog.
① A database containing 200 million protein structures.
② This is 1,000 times larger than the approximately 200,000 protein structures experimentally determined by humankind over the past 50 years.
③ This achievement was made in just one year after the database project began.
Figure 1. AlphaFold2 database size
2. Protein Series
⑴ Albumin
⑶ Galectin
⑸ eGFP
⑹ HSP (Heat Shock Protein)
⑻ RGD
⑼ MUC1
⑽ p53 (TP53)
⑾ HLA
⑿ Siglec
⒀ K-Ras
⒁ EGFR
⒂ A few remarkable point mutations
① BRAF V600E (766 aa, V→E at pos 600)
② EGFR T790M, L858R, C797S
③ IDH1 R132H, R132C, R132G
④ IDH2 R140Q, R172K
⑤ KRAS G12C
⑥ BCR-ABL1 T315I (chimeric fusion protein; requires BCR exon 1-13 + ABL1 kinase domain reconstruction)
⑦ CD74-ROS1
⑧ EZR-ROS1
⑨ JAK2 V617F
⑩ EGFR exon20 insertions
3. Nucleic Acid Series
⑴ Adenine (A, adenine)
⑵ Guanine (G, guanine)
⑶ Thymine (T, thymine)
⑷ Cytosine (C, cytosine)
⑸ Uracil (U, uracil)
⑹ eRNA(enhancer RNA)
4. Other Categories
⑴ RNP (RNA-protein complex)
① Average human protein: 55 kDa. 1 protein. The protein surface area is approximately 19 nm².
② Average human mRNA: approximately 3 kilobases. More than 18 proteins are attached. The protein surface area is approximately 342 nm², and the RNA surface area is approximately 707 nm².
③ Very long noncoding mRNA: approximately 7 kilobases. More than 40 proteins are attached. The protein surface area is approximately 760 nm², and the RNA surface area is approximately 2,000 nm².
Input: 2021.10.11 11:12