○ (+) ABCC11, APOBEC3B, AR, CAV1, CCND1, CDH1, CEACAM6, CENPF, CXCL12, EGFR, ERBB2, ESR1, FOXA1, GATA3, KIT, KRT7, LDHB, LRRC15, MDM2, MKI67, PCLAF, PGR, PTGDS, RUNX1, S100A4, SCD, SFRP1, SNAI1, TACSTD2, TCF4, TOP2A, ZEB1, ZEB2

⑹ ciliated epithelial cell

① (+) FOXJ1, PAEP, UCA1, SCGB1D2, RP11-519G16.5, DCDC2, C2orf88, LAMC2, SCGB2A1, OCLN (Tabula Sapiens)

⑺ eye epithelium

① class 1. corneal epithelial cell

○ (+) KRT3, KLF6 (sc-type)

○ (+) KRT12, MUC22, MGARP, CTSV, ERICH5, RP11-96L14.7, CRTAC1, KRT3, RAET1L, CREG2 (Tabula Sapiens)

② class 2. corneal keratocyte

○ (+) LEPR, LCN1, LACRT, FOXL2, NTRK2, OGN, BOC, CHRDL1, OMD, NECAB1 (Tabula Sapiens)

③ class 3. eye photoreceptor cell

○ (+) RBP3, RS1, KCNV2, IMPG1, RDH8, RTBDN, RP11-442N1.1, PDC, CPLX4, RP11-6E9.5 (Tabula Sapiens)

○ 3-1. rod photoreceptor cell

○ (+) Rho, Pdc, NRL, ROM1, CRX, ARR3, CABP4, CACNA1D, DYNLRB2, EDN2, FRMPD2, GJD2, KCNQ5, KCNA4, LRIT1, LRIT2, MAF, MED1, RORB, RP1L1, TSPAN10, TTC8, Gcap2, Samd7, Cerkl, SAMD11, SLC24A1, RP1, PDE6B (sc-type)

○ 3-2. cone photoreceptor cell

○ (+) Arr3, Opn1sw, NRL, ROM1, CRX, ARR3, OPN1LW, OPN1MW, CABP4, CACNA1D, EDN2, GJD2, GNB3, KCNQ5, LRIT1, MED1, RP1L1, THRB, TSPAN10, TTC8, Opmw, SLC24A1, RP1, PDE6B (sc-type)

④ class 4. ocular surface cell

⑤ class 5. retinal pigment epithelial cell

○ (+) EZR, RPE65, BEST1, ANO2, BMP2, BMP4, CLU, EFEMP1, IL4, KCNJ5, MED1, RDH5, RGR, SBSPON, TGFBR1, TMEM98, TTC8, TRAF1, Cerkl (sc-type)

○ (+) AC067969.2, RPE65, ITGAV, LINC00276, TMEM98, BEST1, FHIT, RBP1, RLBP1, ITGB8 (Tabula Sapiens)

⑥ class 6. cancer cell

○ (+) EPCAM (sc-type)

⑦ class 7. uveal tract cell

⑧ class 8. Schwalbe line cell

⑻ gland

① class 1. acinar cell of salivary gland

○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)

② class 2. duct epithelial cell

○ (+) TFCP2L1, ANKRD36C, FOLR1, SCGB3A1, CALML5, DMBT1, LRRC26, AZGP1, CCL28, TCN1 (Tabula Sapiens)

③ class 3. duodenum glandular cell

○ (+) TFF2, LIPF, C6orf58, GOLM1, A4GNT, KCNE2, FUT9, PGC, AGR2, SCG5 (Tabula Sapiens)

④ class 4. epithelial cell of lacrimal sac

○ (+) SMR3A, PROL1, DCT, LCN1, LINC01474, LACRT, ANGPTL7, KRT12, RP11-54H7.4, PLCB4 (Tabula Sapiens)

⑤ class 5. lacrimal gland functional unit cell

⑥ class 6. luminal epithelial cell of mammary gland

○ (+) SERPINA3, EGLN3, PRSS8, ANGPTL4, HILPDA, ITGB6, RP5-857K21.6, EFHD1, SERINC2, DSG2 (Tabula Sapiens)

○ (+) KRT18, SLPI, KRT19, CD74, AGR2, SERPINB3, WFDC2, LCN2, BTG1, CLDN4, ANXA1, HMGA1, TNFSF10, HIF1A, CEBPD, KRT8, CD9, AQP3, CDH1, MUC1 (PanglaoDB)

⑦ class 7. mucus secreting cell

○ (+) MUC5AC, BPIFA1, MUC5B, ANKRD36C, BPIFB1, LINC00342, SLC5A8, MUC4, SLC26A4, TMC5 (Tabula Sapiens)

⑧ class 8. salivary gland cell

○ (+) Gstm1, Wfdc18

○ (+) CENPF, NEK2, DEPDC1, TOP2A, MKI67, ANLN, IQGAP3, HMMR, MUC7, KLK5 (Tabula Sapiens)

⑨ class 9. secretory cell

⑩ class 10. stratified squamous epithelium from the oral mucosa

○ (+) Krt5, Krt15

⑪ class 11. mammary epithelial cell

○ (+) SERPINB5, KRT5, CLDN4, KRT17, NEDD9, KRT19, KRT7, KRT8, KRT18 (PanglaoDB)

⑫ class 12. parathyroid gland

○ 12-1. oxyphil cell

○ 12-2. parathyroid chief cell

⑬ class 13. breast glandular cell

○ (+) ADAM9, AGR3, ALDH1A3, AQP3, BACE2, C15orf48, C5orf46, CCDC6, CD9, CDC42EP1, CLIC6, CTTN, DAPK3, DMKN, DNTTIP1, DSC2, EIF4EBP1, ENAH, FASN, FLNB, HMGA1, HOOK2, HPX, JUP, KRT23, LYPD3, MLPH, MYO5B, OCIAD2, OPRPN, PIGR, PTRHD1, QARS, S100A14, SCGB2A1, SDC4, SERHL2, SERPINA3, SH3YL1, SLC25A37, SLC5A6, SMS, SQLE, SRPK1, SVIL, TCIM, TMEM147, TOMM7, TPD52, TRAPPC3, USP53, ZNF562

⑼ hepatic epithelium

① class 1. cholangiocyte: bile duct

○ (+) SSTR2, SLC4A2, KRT7, KCNN2, ITGB4, GGT6, CFTR, AQP4, AQP1, PIGR, GGT1, JAG1, GPBAR1, GGT7, KRT19, ONECUT2, ALPL, HNF1B, ALB, AGR2, TFF3, TFF1, SOX9, EPCAM, CLDN4, MMP7, TFF2, SCGB3A1, FXYD2, DEFB1, CD24, LCN2, CXCL1, CXCL6, LGALS2, TACSTD2, ELF3, SPP1, MUC5B, LGALS4, KRT8 (sc-type)

○ (+) CHST4, FGFR2, GC, TM4SF4, APCS, AMBP, AGT, SLC17A4, SEMA3E, CXCL6 (Tabula Sapiens)

○ (+) PIGR, KRT19, AGR2, TFF3, EPCAM, CLDN4, CD24, LCN2, ELF3, LGALS4 (PanglaoDB)

② class 2. cancer stem cell

○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1

⑽ intestinal epithelial cell

① (+) TRDC

② (+) UNC5CL, C1orf177, TRIM31, LINC00955, RP3-417L20.4, HMGN1P20, ALPI, RP11-395B7.2, EGFR-AS1, RP11-462G2.1, DEFB1, CA7, RP11-468N14.13, ARL14, AC024592.9 (sc-type)

③ class 1. enterocyte of epithelium of large intestine

○ (+) 2610528A11Rik

○ (+) MUC12, NXPE1, CLDN3, PHGR1, CDX1, MUC13, RP11-357H14.17, FXYD3, LGALS4, CDH17 (Tabula Sapiens)

④ class 2. enterocyte of epithelium of small intestine

○ (+) RBP2, CCL25, MUC17, PRAP1, CGN, SI, ARL14, FABP2, EPS8L3, CDHR5 (Tabula Sapiens)

⑤ class 3. paneth cell of epithelium of large intestine

⑥ class 4. paneth cell of epithelium of small intestine

○ (+) GOLM1, CTSE, ANXA10, ONECUT2, CDHR5, TSPAN8, CDHR2, KRT20, MUC3A, SLC5A1 (Tabula Sapiens)

⑦ class 5. paneth cell of colon

○ (+) CA7, OTOP2, BEST4, GUCA2A, FRMD1, SPIB, CLDN3, HEPACAM2, KRT20, SDCBP2 (Tabula Sapiens)

⑧ class 6. serous cell of epithelium of bronchus

○ (+) C6orf58, CXCL17, CCDC129, LINC01482, PRR4, BPIFB1, DMBT1, ATP12A, TCN1, GLYATL2 (Tabula Sapiens)

⑨ class 7. serous cell of epithelium of trachea

○ (+) GLYATL2, BPIFB1, PROM1, MUC5B, BPIFA1, TMC5, SCGB3A1, AGR2, DMBT1, FCGBP (Tabula Sapiens)

⑩ class 8. mesothelial cell

○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)

⑪ class 9. BEST4+ cell

⑫ Region 1. villus tip

○ (+) CREB3L3, KLF6, ATF3, JUN, ACE2, MEP1A/B, DEFB1 (antimicrobial peptide), chylomicron assembly (MTTP, APOB, DGAT2), BMP molecules (BMP8A, BMP8AB), non-canonical WNT ligand (WNT5A), gene markers of γδ T/NK (TRDC, GZMA, GZMB)

○ 1-1. villus tip in mouse

○ (+) Sct, enterocyte purine metabolism gene (Enpp3, Ada, Nt5e, Slc28a2), Ido1 (goblet cell gene), immuno suppressive genes

○ (-) Il18

○ 1-2. villus tip in human

○ (+) MHC-I (HLA-A, HLA-B), MHC-II (HLA-DRA, HLA-DRB1, CD74), IL18, pro-inflammatory macrophage genes (C1QC, NLRP3, ADAMDEC1)

⑬ Region 2. mid-villus region

○ (+) PPARD, HNF1B, TG resynthesis enzyme (MOGAT2, MOGAT3, DGAT1)

⑭ Region 3. villus bottom

○ (+) GSTA2, most classic tuft cell marker (TRPM5, IL17RB, PLCG2, SH2D6, LY6H), SLC11A2 (iron import), AQP1, SCTR, IL11RA, antimicrobial proteins (REG3B, REG3G), TMEM159, BSCL2

⑮ Region 4. crypt

○ (+) MYC, HES1, TFRC (iron import), AQP1, SCTR, IL11RA, defense response (REG3A, DMBT1), TMEM159, BSCL2, BMP4, BMP-inhibiting molecules (GREM1, GREM2), WNT ligands (WNT2, WNT2B, WNT10A/B)

○ 4-1. crypt in mouse

○ (+) Sst, Chgb

⑾ kidney epithelial cell

① (+) NAT8, AC093326.1, SLC13A1, MIOX, TMEM27, GLYAT, PDZK1, TINAG, BBOX1, AC009014.3 (Tabula Sapiens)

② class 1. loop of Henle cells

○ (+) UMOD, AQP1, IRX1, IRX2, IRX3, MECOM, POU3F3, TBC1D4, SLC12A1, DEFB1, GEM, RGS5, CYP4B1, DRAM1, NEK6, CDKN1C, CALCRL, CLCNKA, CRYAB, SPP1, PPP1R1B, LRRC66, IGF1, CLDN1, CLDN10 (sc-type)

○ (+) CXCL1, GEM, THBS1, PTGS2 (PanglaoDB)

○ 1-1. loop of Henle ascending limb epithelial cell

○ (+) Slc12a1, Umod, Egf, Wfdc15b, Gpx6, Nccrp1, Clcnka, Ppp1r1a, Kng2, Cldn19 (Tabula Muris)

○ 1-1-1. loop of Henle thick ascending limb epithelial cell

○ (+) KNG1, FXYD2, UMOD, LOC109729779, ATP1B1, ATP1A1, LOC105865250, SLC12A1, DNASE1, LDHB (Tabula Microcebus)

○ 1-1-2. loop of Henle thin ascending limb epithelial cell

○ (+) SPP1, FXYD2, WFDC2, ZC3H10, KNG1, UMOD, CTSD, S100A6, RPS18, TMEM176B, (Tabula Microcebus)

○ 1-2. loop of Henle descending limb epithelial cell

○ 1-2-1. loop of Henle thick descending limb epithelial cell

○ 1-2-2. loop of Henle thin descending limb epithelial cell

○ (+) SPP1, CLU, ZC3H10, PTGDS, FXYD2, RPS18, AQP1, RPL26, CTSD, S100A6 (Tabula Microcebus)

③ class 2. collecting duct cell

○ (+) Slc12a3, Rhcg, Calb1, Spink8, Pgam2, Uroc1, D630042F21Rik, Hsd11b2, Slc26a4, Emx1 (Tabula Muris)

○ 2-1. α-intercalated cell

○ (+) ATP6V1G3, ATP6AP2, RHBG, ATP1B1, LOC109729779, RHCG, LOC105879013, FOXI1, AQP6, AU129_gr01 (Tabula Microcebus)

○ (+) FOXI1, OXGR1, ATP6V1G3, AQP6, CA2, NR1I4, SLC4A1, RHCG, ATP6V1B1, AVPR1A, P2RY14, FXYD2, TMEM213, CA2, DMRT2 (sc-type)

○ 2-2. β-intercalated cell

○ (+) FOXI1, OXGR1, ATP6V1G3, SLC26A4, CA2, NR1I4, RHCG, ATP6V1B1, AVPR1A, INSRR, FXYD2, TMEM213, CA2, AP1S3 (sc-type)

○ 2-3. principal cell

○ (+) KCNE1, APELA, AQP2, AQP3, GATA3, ELF5, STC1, TBX3, CLDN4, KCNJ1, AVPR2, FXYD4, HSD11B2, SCNN1G (sc-type)

○ 2-4. inner Medullary cell

○ (+) S100A4, PLEKHB1, ALDH1A3, TM6SF1, SLC14A2 (sc-type)

④ class 3. renal tubular cell

○ (+) Dach1, Calb1

○ 3-1. renal distal tubule cell

○ (+) KLK1, KCNJ1, KL, EGF, TMEM213, TMEM52B, SOSTDC1, SLC12A3, EMX1, CLDN3, CLDN8, UMOD, PCOLCE, CDC42EP3, CLCNKB, FXYD2, POU3F3 (sc-type)

○ 3-2. renal proximal tubule cell

○ (+) 0610005C13Rik

○ (+) FXYD2, ATP1B1, SLC3A1, CUBN, PDZK1, LRP2, POU3F3, AGXT2, GSTA2, CYP2E1, CRYL1, GLYAT, SORD, UPB1, SOD3, HNF4A, CDKN3, NAPSA, SLC7A13, SLC17A3, HGD (sc-type)

○ (+) DPP4, ENPEP, LRP2, PDZK1, SLC34A1, ASS1, PCK1, SLC4A4, GLYAT, FBP1, FOLR1, AK4, SLC5A8, FAH, CRYL1, SLC13A1, TMEM27, APOE, HGD, SERPINF2 (PanglaoDB)

○ 3-2-1. kidney proximal straight tubule epithelial cell

○ (+) Spink3, Slc34a1, Slc39a5, Miox, Slc13a1, Rdh16, Ugt2a3, Lrrc19, Pck1, Slc22a8 (Tabula Muris)

○ (+) ALDOB, FXYD2, GPX3, MIOX, SMIM24, APOC3, LOC105867418, SPP1, AQP1, AU129_gr01 (Tabula Microcebus)

○ 3-2-2. kidney proximal convoluted tubule epithelial cell

○ (+) GPX3, ALDOB, FXYD2, MIOX, APOC3, LOC105866477, SMIM24, AU129_gr01, SLC34A1, LOC105867418 (Tabula Microcebus)

○ 3-3. connecting tubule cell

○ (+) CALB1, TRPV5, FXYD2, ATP6V1B1, SLC8A1 (sc-type)

⑤ class 4. ureteric bud cell

○ (+) GFRA1, RET, WNT9B, CLDN6, LAMA1, NMU, Wnt11, Etv4, WNT7B (sc-type)

⑥ class 5. conjunctival epithelial cell

○ (+) AQP5, POLR2J3, FAM83A, PAX6, GJB4, SYT8, SOX15, FGFBP1, SERPINB2, FAM110C (Tabula Sapiens)

⑿ lung epithelium

① class 1. airway epithelial cell

○ (+) ADH7, AQP1, CDH1, SEC14L3 (sc-type)

② class 2. epithelial cell

○ (+) ANPEP, EPCAM, IL10, IL6R (sc-type)

③ class 3. alveolar epithelial cell

○ (+) T1a, AQP5

④ class 4. bronchial epithelial cell

○ (+) MUC5AC

⑤ class 5. Typei pneumocyte (alveolar Typei, AT1)

○ (+) GPRC5A, AGER, RTKN2

○ (+) AGER, AKAP5, AQP3, AQP5, CCN2, CLDN18, CLIC5, COL4A3, COL4A4, CRLF1, CYP4B1, EGFL6, EMP2, FSTL3, GPRC5A, HOPX, ICAM1, IGFBP6, KRT7, MEX3B, MMP11, P2RX7, PDPN, PXDC1, RTKN2, SCNN1A, SCNN1B, SCNN1G, SEC14L3, SEMA3B, SEMA3E, SMARCA1, VEGFA (sc-type)

○ (+) AGER, GGTLC1, MS4A15, CEACAM6, ANKRD29, AQP4, C4BPA, KAL1, ATP13A4, ARHGEF26 (Tabula Sapiens)

⑥ class 6. Type ii pneumocyte (alveolar Typeii, AT2)

○ (+) SFTPB, SFTPC, MUC1, SLC34A2, Foxp2, Nkx2-1, Tmem213, LYZ, ALPL

○ (+) ABCA3, ADGRF5, AGER, CD36, CD3G, CEBPA, CLDN18, CRLF1, CTNND1, CXCL2, CXCR2, DDX3Y, EGFL6, ETV5, GRK2, IL1B, INMT, IRX1, LAMP3, LPCAT1, LRG1, MUC1, NAPSA, NKX2-1, NRN1, PGC, PIGR, PPBP, PPP1R14C, RUNX3, S100G, SDC1, SFTA2, SFTPA1, SFTPB, SFTPC, SFTPD, SLC34A2, SOAT1 (sc-type)

○ (+) GKN2, SFTPA1, SFTPA2, SLC22A31, SFTPC, SFTPD, ROS1, NAPSA, ABCA3, CACNA2D2 (Tabula Sapiens)

○ (+) SFTPC, LOC105870139, LOC105873688, LOC105883485, SFTPB, TMSB4X, LOC105879971, SFTPD, CTSH, CXCL17 (Tabula Microcebus)

○ (+) NKX2-1, MUC1, CLDN18, LAMP3, SFTA2, SFTPD, SLC34A2, SFTPB, SFTPA1, SFTPC, ADGRF5, LPCAT1, NAPSA, ABCA3, PGC, CXCL2, PIGR (PanglaoDB)

⑦ class 7. cycling epithelial cell

⑧ class 8. ECM-high epithelial cell

⑨ class 9. tuft-like

⑩ class 10. club cell

○ (+) Scgb3a2, S100a6, Aqp5

○ (+) CYP2B7P, FOLR1, NEDD4L, KIAA1244, SCGB3A1, AGR3, OCLN, SHROOM3, ERBB2, CXCL17 (Tabula Sapiens)

○ 10-1 airway club cell

⑪ class 11. trachea double-positive, alpha-beta thymocyte

⑫ class 12. mesothelial cell

○ C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)

⑬ class 13. tracheal goblet cell

○ (+) MUC5AC, RP11-412H8.2, BPIFA1, BPIFB1, MUC5B, ATP12A, CXCL17, AGR2, VMO1, LCN2 (Tabula Sapiens)

⒀ myoepithelial cell

① (+) KRT1

② (+) FBXO2, MYLK, ACTG2, SYNM, TFAP2C, KCNMB1, FAT1, SAA1, MIR143HG, KRT17 (Tabula Sapiens)

③ class 1. breast myoepithelial cell

○ (+) ACTG2, C6orf132, DSP, DST, GLIPR1, KARS, KLF5, KRT5, KRT6B, MYLK, NARS, OXTR, PTN, TRAF4, TUBB2B

⒁ neuroepithelial cell

① (+) NES, SOX2, NOTCH1, HES1, HES3, CDH1, OCLN, SOX10 (sc-type)

⒂ pancreatic epithelium

① class 1. cancer stem cell

○ (+) CD24, CD44, FLOT2

② class 2. pancreatic ductal cell

○ (+) CFTR, HNF1B, KRT20, MUC1, ONECUT1, AMBP, HHEX, ANXA4, SPP1, PDX1, CFB, GDF15, AKR1C3, MMP7, DEFB1, SERPING1, TSPAN8, CLDN10, SLPI, SERPINA5, PIGR, CLDN1, LGALS4, PERP, PDLIM3, WFDC2, AQP1, ALDH1A3, KRT19, TFF1, TFF2 (sc-type)

○ (+) SLC4A4, CFTR, CLDN10, RP11-528G1.2, SCTR, PKHD1, SFRP5, DCDC2, ANXA4, RP11-680F8.1 (Tabula Sapiens)

○ (+) GDF15, MMP7, SLPI, PERP, WFDC2, KRT19, KRT7, CLDN4, TACSTD2, CTSH, S100A10 (PanglaoDB)

⒃ prostate epithelium

① class 1. basal cell of prostate epithelium

○ (+) HCAR2, HCAR3, CYP4F8, RMST, HOXB8, SLC16A12, SPINK2, TNS4, GATA3-AS1, PIK3C2G (Tabula Sapiens)

② class 2. club cell of prostate epithelium

③ class 3. glandular cell

④ class 4. hillock cell of prostate epithelium

⑤ class 5. hillock-club cell of prostate epithelium

⑥ class 6. luminal cell of prostate epithelium

○ (+) KLK3, KLK2, ACPP, LINC01297, KLK4, NEFH, RP11-356O9.1, RPL7P16, RP11-388N2.1, NKX3-1 (Tabula Sapiens)

⒄ squamous epithelial cell

⒅ stomach epithelial cell

① class 1. ciliated epithelial cell

○ (+) CCDC37, C11orf88, FAM216B, LDLRAD1, TUBA4B, KIF19, DYDC2, ANKRD66, C9orf117, C10orf67, AC013264.2, LRRC71, CAPSL, TSPAN19, STOML3 (sc-type)

② class 2. squamous epithelial cell

○ (+) KRT6B, CAPNS2, KRT6C, FGFBP1, KRT6A, KRT17, ADH7, SERPINB10, KRT16, S100A3, CLCA2, LY6D, KRT4, AC019349.5, GPR87 (sc-type)

③ class 3. mesothelial cell

○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP, PTPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)

⒆ surface ectodermal cell

① (+) CCL21, RELN, MMRN1, PKHD1L1, ANGPT2, WFS1, SCN3B, SEMA3A, PIEZO2, PROX1 (Tabula Sapiens)

⒇ thymic epithelial cell

① (+) Tcrg-C1, Tbata

② (+) RP11-81F13.2, KCNJ5, RP11-153K16.1, RP11-81F13.1, LL22NC03-75H12.2, RP11-112J1.2, RP11-114G22.1, RP6-24A23.6, C11orf16, SLC46A2, CACNA1I, PTPRT, NPFFR2, RP1-223B1.1, C12orf56 (sc-type)

③ class 1. DN3 thymocyte

○ (+) TRBV25-1, TRAC, BCL11B, AP3M2, CD48, RPL22, TRBC2, RRN3P1, CD3D, TCF7 (Tabula Sapiens)

④ class 2. DN4 thymocyte

○ (+) CENPF, TOP2A, KIFC1, KIF14, CEP55, FAM72B, NUSAP1, UBE2C, KIF15, TPX2 (Tabula Sapiens)

⑤ class 3. double-positive, alpha-beta thymocyte

⑥ class 4. medullary thymic epithelial cell

⒇ bladder epithelium

① class 1. bladder cell

○ (+) Asz1, Tgm5, Car3, Cck, Pitx1, Cntn4, Krtdap, Prss35, Hoxa11, Cpz (Tabula Muris)

② class 2. bladder urothelial cell

○ (+) DHRS2, BTBD16, UPK1A, TRIM31, PADI3, ATP1A4, PSCA, APOL1, VSIG2, UPK3A (Tabula Sapiens)

○ (+) Krt39, Muc15, Sprr2b, Ugt2b35, Gpa33, Upk1a, Sprr1a, Ivl, Gjb6, 1110032A04Rik (Tabula Muris)

○ (+) ZC3H10, RPS27, RPS18, RPLP1, RPS28, S100A6, RPL37, LOC105857397, RPL36, RPL37A (Tabula Miceocebus)

⒇ uterus epithelium

① class 1. epithelial cell of uterus

○ (+) LINC01541, ASRGL1, UCA1, SCGB2A1, PAEP, STX18, SEMA3B, DLX5, PAPSS1, ITGB8 (Tabula Sapiens)

⒇ mesothelial cell

① (+) SERTM1, SYT4, ITLN1, GALNT9, MGAT4C, UPK3B, PTPRQ”, RP11-826N14.4, TMTC2 (Tabula Sapiens)

② (+) INS, REG3G, RPS18, S100A6, ZC3H10, TMSB4X, LOC105875474, RPS27, PRSS2, S100A4 (Tabula Microcebus)

③ (+) CALB2, MUC16, KRT5, KRT7, MSLN, WT1, PKHD1L1, SULF1, MIR22HG, COBLL1, GBP2, MEDAG, CRLS1, EFEMP1, RSPO1, RARRES2 (PanglaoDB)

④ class 1. lung mesothelial cell

○ (+) C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)

⑤ class 2. intestine mesothelial cell

○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)

⑥ class 3. spleen mesothelial cell

○ (+) QRFPR, SLPI, LHX9, PLA2G2A, CGN, NPHS1, KRT5, LRRN4, KLK11, OLR1, PTPRQ, COL8A1, PDZK1IP1, HAS1, SFRP2 (sc-type)

⑦ class 4. stomach mesothelial cell

○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP,P TPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)

⒇ tongue epithelium

① class 1. taste receptor cell

② class 2. salivary mucuous cell

○ (+) KRT14, THBS1, KRT17 (PanglaoDB)

③ class 3. acinar cell of salivary gland

○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)

⒇ olfactory epithelial cell

⒇ skin epithelium

① class 1. keratinocyte

○ (+) KRT4, IGFL1, LGALS7, SPINK5, RHCG, GBP6, IVL, CYSRT1, THEM5, SULT2B1 (Tabula Sapiens)

○ (+) CALML5, CD24, KRT5, KRT14, KRT17, AQP3, KRT15, S100A14, SFN, KRT10 (PanglaoDB)

○ 1-1. spinous cell (prickle cell)

○ (+) Krt1, Krt10

○ 1-2. basal cell

○ (+) Krt14, Krt5

○ 1-3. proliferating basal cell

○ (+) Mki67, Krt14, Krt5

② class 2. melanocyte

③ class 3. merkel cell

④ class 4. sebocyte

⑤ class 5. trichocyte

⑥ class 6. hair follicle (HF)

○ 6-1. hair follicle associated cell

○ (+) Krt15, Krt17, Krt79

○ 6-2. HFSC (hair follicle stem cell)

○ (+) Lgr5, Cd34

○ 6-3. infundibulum

⑦ region 1. epidermis

○ (+) Krt5, Krt14

⑧ region 2. dermis

○ (-) Krt5, Krt14

3. Type 2. endothelial cell

⑴ overview: pan-endothelial cell

① (+) CD31(PECAM1), CD34, VWF, PLVAP, CDH5, TIE-2, Axin2, WARS, AQP1, TIFA, Cyyr1, Hspa1b, NCOA7, DUSP23

② (+) PECAM1, CD34, KDR, CDH5, PROM1, PDPN, TEK, FLT1, VCAM1, PTPRC, VWF, ENG, MCAM, ICAM1, FLT4, SELE (sc-type)

③ (+) TM4SF18, PLVAP, WWTR1, MKL2, SOX18, CD320, S1PR1, NOTCH4, RAPGEF5, LIMS2 (Tabula Sapiens)

④ (+) Tlx1, Gm694, C1qtnf9, Kcna5, Rbp7, Fabp4, Aqp7, Glycam1, Apold1, Sele (Tabula Muris)

⑤ (+) PECAM1, VWF, CLEC14A, EMP1, RNASE1, CTGF, HYAL2, CALCRL, EMCN, ADGRL4, CLDN5, ECSCR, CDH5, TGFBR2, ENG, EGFL7, FLT1, EPAS1, CD34, SRGN, S100A10, IGFBP7, SPARC, SLC9A3R2, MGP, SPARCL1, TM4SF1, ID1, CD9, ID3, CAV1, GNG11, S100A13,IFI27, PCAT19, TIMP3 (PanglaoDB)

⑥ (+) CLDN5, TIE1, VWF, KDR, ROBO4, EMCN, MYCT1, HYAL2, TEK, ACVRL1, FLT4, MMRN2, ANGPT2, ARHGEF15, CD93 (SCEVAN)

⑵ adrenal vascular endothelial cell

① (+) CCL23, FGF23, SMIM9, RP13-1016M1.2, RP11-100L22.1, RP11-327L3.3, RP1-149A16.12, GPR182, DLL4, GALNT15, CALCRL, CD300LG, FLT4, FCN3, GPIHBP1 (sc-type)

⑶ angiogenic endothelial cells

① (+) CD105, VEGFR2, KIT, NRP2, COL15A1, PCDH17, ITGA6

⑷ pericyte cell: Fibroblast-like cells that wrap around endothelial cells

① (+) NG2, Rgs5, Abcc9

② (+) GUCY1A2, COX4I2, NDUFA4L2, RGS5, NOTCH3, GJA4, GUCY1B3, FHL5, STEAP4, C2orf40 (Tabula Sapiens)

③ (+) PDGFRB, NOTCH3, COX4I2, HIGD1B, MCAM, NDUFA4L2, VIM, MFGE8 (PanglaoDB)

⑸ tissue 1. cardiovascular system

① class 1. artery endothelial cell

② class 2. capillary aerocyte

③ class 3. capillary endothelial cell

○ (+) FCN3, CA4, GPIHBP1, CD300LG, CDH5, PODXL, ROBO4, EMCN, BTNL9, HYAL2 (Tabula Sapiens)

○ (+) LOC105857591, B2M, LOC105855951, RAMP2, CD74, LOC105867540, MFGE8, CALCRL, RAMP1, LOC105856764 (Tabula Microcebus)

④ class 4. cardiac endothelial cell

○ (+) H19, CLIC5, F8, SLC14A1, TNNT3, MCF2L, KANK3, TMEM88, TCF15, TSPAN18 (Tabula Sapiens)

⑤ class 5. endothelial cell of artery

○ (+) IGFBP3, SEMA3G, MECOM, HEY1, CLEC14A, KIAA1462, JAM2, EFNB2, PIK3R3, SHE (Tabula Sapiens)

⑥ class 6. endothelial cell of vascular tree

○ (+) SELE, IL6, RND1, CNKSR3, STC1, SELP, ACKR1, SOX7, ADAMTS9, OLFM1 (Tabula Sapiens)

⑦ class 7. vein endothelial cell

○ (+) CCL14, OLFM1, ACKR1, DOC2B, PLVAP, FAM110D, RAMP3, SELP, LPCAT4, SLCO2A1 (Tabula Sapiens)

○ (+) TMSB4X, ZC3H10, ACKR1, RPS18, LOC105857591, ADIRF, SELE, B2M, RPS12, RPL37A (Tabula Microcebus)

⑧ class 8. endothelial cell of lymphatic vessel

○ (+) LYVE1

○ (+) MMRN1, CCL21, PKHD1L1, PROX1, FLT4, SMAD1, TFF3, NR2F1, RHOJ, LAYN (Tabula Sapiens)

○ (+) CCL21, B2M, ADIRF, VIM, RAMP2, TMEM176B, PLAC9, MMRN1, TIMP3, LOC105855951 (Tabula Microcebus)

⑨ class 9. lymphatic endothelial cell of heart

○ (+) GPR182, GPR97, STAB2, HOXD9, TBX1, CCL21, HOXD10, TSPEAR, ABCA4, PGM5-AS1, TFF3, LINC00636, RP11-341G23.4, HOXD4, RP11-451M19.3 (sc-type)

⑩ class 10. vascular endothelial cell of heart

○ (+) ESM1, SLC9C1, OPN5, QRFPR, MIR4454, AC007743.1, PKD1L1, TM4SF18, APLNR, CLRN1-AS1, CD300LG, C1QTNF9, AC019100.3, MADCAM1, RP11-298O21.5 (sc-type)

⑪ class 11. blood vessel endothelial cell

○ (+) EPHX4, POSTN, CCL14, TMEM255B, LCN6, CYTL1, NOS3, ACKR1, RILPL1, HSPA12B (Tabula Sapiens)

○ region 1. tunica intima

○ region 2. tunica media

○ region 3. tunica adventitia

⑫ class 12. vasa recta ascending limb cell

○ (+) LOC105855951, B2M, HYAL4, LOC105869179, LOC105871594, LOC105870764, LOC105870765, S100A6, RAMP2, CD74 (Tabula Microcebus)

⑬ class 13. vasa recta descending limb cell

○ (+) S100A6, AQP1, TIMP3, S100A4, TMSB4X, LOC105855951, HSPB1, MGP, B2M, JUN (Tabula Microcebus)

⑹ tissue 2. digestive system

① class 1. endothelial cell of hepatic sinusoid

○ (+) OIT3, CRHBP, CLEC4G, IL33, INSR, DNASE1L3, HECW2, BMPER, FAM167B, NTN4 (Tabula Sapiens)

② class 2. gut endothelial cell

○ (+) PCAT19, GPR126, FOXC1, JAM2, NRN1, CLDN5, SLCO2A1, THBD, PTPRB, ICAM1 (Tabula Sapiens)

③ class 3. liver endothelial cell

○ (+) FLT1, APPBP2, ARGLU1, ATP10D, BNIP1, BST2, BTNL9, C11orf96, CCDC85B, CCL14, CD4, CDC73, CDKL1, CHD4, CLEC1B, CLEC2B, CLEC4G, CLEC4M, CRBN, CRHBP, CTSL, DCLRE1C, DIPK2A, DLC1, DLG1, DLK1, DNASE1L3, DOCK1, DUSP5, EFNB2, ENG, F8, FCN2, FCN3, FILIP1, FOSB, FXYD6, GBP4, GGA2, GNG11, HES1, HYI, IL1R1, IL33, KDR, KIF1B, KLHL28, LDB2, MCAM, MCM3AP, MEF2C, MFN1, MGAT5, MPZL3, MRC1, OIT3, PIK3C2A, PPWD1, PTPRC, RASGEF1B, RASGRP3, RELN, RIN2, SECISBP2L, STAB1, STRN3, TCF12, TEX264, TFRC, TRAPPC11, TSPAN7, USP48, VWF, ZNF286B, STAB2, CD34, PECAM1 (sc-type)

④ class 4. vascular endothelial cell of intestine

○ (+) SOX17, GPIHBP1, PRND, CLEC3B, FLT1, MMRN2, BTNL9, APLNR, LHX6, NOTCH4, RP11-3K16.2, ESAM, RP11-328D5.1, ESM1, GJA5 (sc-type)

⑤ class 5. lymphatic endothelial cell of intestine

○ (+) RP11-474N8.5, TBX1, STAB2, CCL21, LINC00636, TSPEAR, ART5, CTC-236F12.4, GPR1, RP11-322E11.5, MPP7, Y_RNA, ABCA4, PLIN5, TP63 (sc-type)

⑥ class 6. vascular endothelial cell of stomach

○ (+) SELE, PRND, APLNR, ARHGEF15, PLVAP, FLT1, PCDH12, MADCAM1, GPIHBP1, GALNT15, RP4-601K24.1, MEOX1, A2M, CCM2L, CLEC14A (sc-type)

⑦ class 7. lymphatic endothelial cell of stomach

○ (+) NTS, STAB2, CCL21, RADIL, RP11-444A22.1, TFPI, RP11-142C4.6, TNFAIP8L3, LY86-AS1, PTGS2, RP11-554D15.1, EFCC1, MMRN1, Y_RNA, NFATC1 (sc-type)

⑧ class 8. portal vein

○ (+) Adgrg6, Gja5

⑺ tissue 3. excretory system

① class 1. kidney endothelial cell

○ (+) F8, AU021092, Emcn, Fam167b, Rsad2, Plvap, Esm1, Cldn15, Bhlhe22, Ppap2a (Tabula Muris)

○ (+) TGFBR2, NOTCH4, ADGRL4, EMCN, ENG, PECAM1, PLAC8, PLVAP, TEK, KDR, VWF, MMRN1, CD93 (sc-type)

○ 1-1. renal vesicle cell

○ (+) NCAM1, EMX2, LHX1, BMP2, DKK1, DLL1, GREB1, PAPSS2, PCSK9, POU3F3, TMEM100, WT1 (sc-type)

② class 2. bladder endothelial cell

○ capillary endothelial cell

○ endothelial cell of lymphatic vessel

○ vein endothelial cell

⑻ tissue 4. muscle endothelial cell

① class 1. lymphatic endothelial cell

○ (+) NTS, TFF3, CCL21, STAB2, PTX3, PCLO, IL7, P4HA3,C 6orf141, PIK3C2G, ASGR2, ANKRD36BP2, NALCN, FAM26F, NHLRC1 (sc-type)

② class 2. vascular endothelial cell

○ (+) MIR4454, SLC5A4, AL118508.1, CA4, RP11-206M11.7, PRSS51, NOS3, GRIN2A, GFRAL, CD300LG, MADCAM1, RP11-327L3.3, C1QTNF9, ANO2, AP001597.1 (sc-type)

⑼ tissue 5. nerve system

① class 1. retinal blood vessel endothelial cell

○ (+) LCN1, LACRT, SELP, ELOVL7, SELE, SYT15, MYRIP, CXorf36, THSD7A, CD200 (Tabula Sapiens)

② class 2. eye endothelial cell

○ (+) PECAM1, VWF, CDH5, BMP2, BMP4, CD34, CD55, FLT1, MED1, TGFBR1, TMEM98, TNFSF12, CD93, SLCO1A4, CLDN5, ICAM1, GNG11 (sc-type)

③ class 3. brain endothelial cell

○ (+) PECAM1, VWF, A2M, APOLD1, FLT1, TM4SF1, CD34, MCAM, ENG, PTPRC, VCAM1, CDH5 (sc-type)

⑽ tissue 6. prostate endothelial cell

① (+) PECAM1, CD34, MCAM, CDH5, VWF, ENG, KDR, PDPN, SELE, A2M (sc-type)

⑾ tissue 7. respiratory system

① class 1. lung endothelial cell

○ (+) Cldn5, Hpgd, Rasgef1a, Tmem100, Lyve1, Adrb1, Clec14a, Prx, Ripply3, Sox11 (Tabula Muris)

○ (+) CD34, EGFL7, EMCN, ESAM, FLT1, KDR, MCAM, PECAM1, RAMP2, TEK, VWF (sc-type)

② class 2. bronchial vessel endothelial cell

③ class 3. arterial endothelial cell

④ class 4. capillary endothelial cell

⑤ class 5. inflamed endothelial cell

⑥ class 6. pulmonary venous endothelial cell

⑦ class 7. systemic venous endothelial cell

⑧ class 8. lung microvascular endothelial cell

⑿ tissue 8. vascular endothelial cell of placenta

① (+) RP11-1028N23.4, RP11-297H3.3, AC007743.1, RP11-327L3.3, CD34, ARHGEF15, CXorf36, LRRC36, SOX7, RP11-328D5.1, NTS, CDRT1, LINC01049, ROBO4, HS3ST3A1 (sc-type)

⒀ tissue 9. vascular endothelial cell of spleen

① (+) RP11-189E14.5, ODF3L2, RP4-765C7.2, AC019100.3, RP11-172F10.1, CTD-2207L17.2, RP1-154K9.2, AC010084.1, SLC5A4, OR5G5P, HOXD3, SNTG1, EEF1A1P31, ADAMTSL1, MYRIP (sc-type)

⒁ tissue 10. vascular endothelial cell of thymus

① (+) ADAMTS9, PROX1, MET, AC011526.1, MEOX2, ANO2, CTD-3179P9.1, NOVA2, AOC3, CXorf36, GPR116, PODXL, NRN1, PTPRB, LINC00472 (sc-type)

⒂ tissue 11. tumor-associated endothelial cell (TEC)

① (+) CD144

⒃ tissue 12. lymphovascular

① (+) TFF3, CCL21, TFPI, FABP5, PROX1, RGS16, PPFIBP1, EPHB4, ITGA9, MMM1, PDE2A, IGF1, CD9, LYVE1, FLT4, MAF, NRP2

4. Type 3. immune cell

⑴ immune cell

① (+) LCP2, LSP1, FYB, PLEK, HCK, IL10RA, LILRB1, NCKAP1L, LAIR1, NCF2, CYBB, PTPRC, IL7R, LAPTM5, CD53 (SCEVAN)

② state 1. ISG (interferon-stimulated gene) expressing immune cell

○ (+) IFIT1, IFIT2, IFIT3, IFIT5, ISG15, CCL3, CCL4, CCL3L3, RSAD2, OASL, CXCL10, IFI15, ISG20 (sc-type)

⑵ Category I. leucocyte (leukocyte, white blood cell)

① (+) CD45

② (+) SPRR2D, S100A7, SPRR2E, TIPARP, RUNX3, CD3G, GLIPR1, GPR183, RGS1, SPRR2A (Tabula Sapiens)

③ category A. lymphoid cell

○ (+) NK1.1, B220, CD4, CD8

○ (+) CCL5, TMSB10, RPS27, LOC105874071, RPL13A, RPLP1, IL32, RPS11, GZMA, RPS15A (Tabula Microcebus)

○ state 1. innate lymphoid cell

○ (+) TCF7, CD69, TAGAP, AREG, TRAC, PIK3IP1, IL7R, CXCR4 (Tabula Sapiens)

④ category B. myeloid cell

○ (+) CD68, CD14, CD11b, ITGAX (CD11c), ADGRE1, MHC-II, Ly6G, Ly6C, CD86, HLA-DRA, F4/80, CST3, LYZ, Lamp3

○ (+) GPR34, CCR1, HLA-DRB5, C3AR1, CD68, CSF1R, SLC1A3, CLEC7A, MAFB, SIGLEC10 (Tabula Sapiens)

⑶ A-1. B cell (B lymphocyte)

① pan-B cell

○ (+) CD19 (almost exclusively in B cells), CD20 (MS4A1), CD79A, CD79B, BLK, PTPRC, CD24, CD40, CD72, CD220, APOBEC3A, PELI1, ANKRD28, C2orf42, CCPG1, CLECL1, DNAAF1, DUSP5, ERN1, FAM107B, ITM2, LGALSL, RAB30, SLAMF1, TRIB1, VOPP1, TNFRSF5, CLEC2C, FCRL4, HAVCR1, CR2, IL35, LILRB1, SPN, TLR9, TNFRSF13C, TNFRSF17, XBP1, MME, Btla, LAT2, BASP1

○ (+) LINC01781, BLK, TNFRSF13B, CD19, VPREB3, LY9, GNG7, BANK1, MS4A1, LINC02397 (Tabula Sapiens)

○ (+) Ms4a1, Cd79a, Crisp3, Faim3, Cd79b, Fcer2a, Tnfrsf13c, Cr2, Bank1, Cd19 (Tabula Muris)

○ (+) CD74, RPS27, RPL12, RPS15A, RPS28, RPL37, LOC105855163, RPL23A, RPL27A, RPS11 (Tabula Microcebus)

○ (+) CD69, CD79A, CD79B, IGHM, HLA-DRA, LTB, MZB1, VPREB3, CXCR4, IGLC2, IGKC, BCL11A, CD74, CD52 (PanglaoDB)

○ (+) HLA-DOB, HLA-DQA1, MS4A1, CD79B, BLK, GNG7, SPIB, TCL1A, FCRLA, HVCN1, NCF1, BANK1, CD79A, CD19, VPREB3 (SCEVAN)

② class 1. pre-pro-B cell

○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, cµ, λ5

○ (-) Cd19, Cd2

③ class 2. pro-B cell

○ (+) CD19, CD20, CD34, CD38, CD45R, CD22

○ (+) CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, DNTT, C10orf10, VPREB1, ARPP21, CD99, IGLL1, CD9, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)

○ 2-1. large-pro-B cell (mouse)

○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, HSA, λ5

○ (-) Cd2, Cd22, Cd117, cµ

④ class 3. pre-B cell

○ (+) CD19, CD20, CD38, CD40, CD45R, CD34, CD79A, CD79B, Pou2af1, Cd93, Elk3, Satb1, Tox

○ (+) CD19, CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, NSMCE1, PCDH9, ACSM3, CCDC191, TCL1A, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)

○ 3-1. large-pre-B cell (mouse)

○ (+) Cd19, Cd45r, Cd127, BP-1, cµ

○ (-) Cd2

○ 3-2. small-pre-B cell (mouse)

○ (+) Cd2, Cd19, Cd127, B220, cµ

○ (-) Cd43, sµ

⑤ class 4. immature B cell

○ (+) CD19, CD20, CD40, CD45R, IgM, CD38, CD5, CD53

⑥ class 5. transitional B cell

○ (+) CD10, CD19, CD20, CD25, CD30

○ (-) CD27

○ 5-1. transitional 1 (T1) B cell

○ (+) B220, Cd19

○ (-) Cd23

○ 5-2. transitional 2 (T2) B cell

○ (+) Cd23, Cd93, B220, IgD

⑦ class 6. marginal zone B cell

○ (+) CD1, CD19, CD20, CD21, CD27, Notch2, Cd1d, Cd21, Cd93, HSA, CD1D

○ (-) Cd35,

⑧ class 7. follicular B cell / B2 cell

○ (+) IgD, CD21, CD22, CD23, Cd19, Cd21, Cd35, Cd93

⑨ class 8. B1 cell

○ (+) Cd11b, CD19, CD20, CD27, CD43, CD70, IgM, CD5

○ (-) Cd23, CD38

○ 8-1. B1 precursor

○ (+) Cd19, Cd45ra

○ (-) B220

⑩ class 9. plasma B cell

○ (+) CD27, CD38, CD40 CD78, CD95, CD138, CD319, IL-6, CXCR4, IGHG3, IGKC, IGHM, IGHG2, IGKV4-1, IGLV3-1, IGHA1, IGHG1, JCHAIN, Cd19, Cd138, IGKC, BCMA, BCL2, BCL6, XBP1, FKBP2, SELM, SSR3, VIMP, SPCS3, ERLEC1

○ (+) CD27, IgD,CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)

○ (+) IGHG1, IGJ (JCHAIN), IGHG3, MZB1, TXNDC5, IGHG2, DERL3, IGLC2, IGHG4, IGLC3 (Tabula Sapiens)

○ (+) LOC109729893, LOC105882024, JCHAIN, LOC105877808, LOC105862709, MZB1, HERPUD1, B2M, RPLP1, RPS18 (Tabula Microcebus)

○ (+) SDC1, CD38, CD27, CYCS, CD74, TNFRSF17, CD79A, EAF2, GNG7, IGKC, MZB1, IGLC2, IGHG1, IGHG2, IGHG3, IGHGP, IGLC3, JCHAIN, IGHA1, IGHG4, IGHA2, SSR4 (PanglaoDB)

○ (-) CD20, CD79A, CD79B, BLNK, MS4A1, IgM, Cd21, Cd22, Cd23, IgD, IgM

○ (-) CD20, MS4A1 (sc-type)

⑪ class 10. memory B cell

○ (+) CD19, CD20, CD27, CD40, CD80, PDL-2, CXCR3, CXCR4, CXCR5, CXCR6, IgA, IgG, IgE, B220, MHC class II, BCL2, CD53, CD21, FAS

○ (+) CD19, CD27, IgD, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, CD27, VPREB3, IGLL5 (sc-type)

○ (+) AIM2, ADAM28, TLR10, CD19, TNFRSF13B, CD22, P2RX5, RP5-887A10.1, SCIMP, MS4A1 (Tabula Sapiens)

○ (-) CD38, CD150

⑫ class 11. regulatory B cell

○ (+) IgD, CD1, CD5, CD21, CD24, TLR4, IL-10, TGFβ

⑬ class 12. NF B cell

○ (+) B220, Cd2, Cd19, HSA, IgM

○ (-) Cd21, Cd23, Cd35

⑭ class 13. activated germinal B cell

○ (+) B220, MHC class II

⑮ class 14. Breg

○ (+) CD1D, CD27, CD5

⑯ class 15. mature B cell

○ (+) CD22, CD21

⑰ state 1. naïve B cell

○ (+) CD19, CD20, CD23, CD40, CD150, IgD, IgM, CD22, CD53, CD21

○ (+) CD19, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)

○ (+) TCL1A, IGHD, LINC00926, FCRL1, STAG3, RP11-693J15.5, FCER2, PAX5, FAM129C, CD22 (tabual sapiens)

○ (+) BANK1, CD37, CD69, CD79A, CD79B, IGHD, IGHM, IGKC, LTB, MS4A1, SELL, TCL1A, VPREB3, FOXP1, CD52, HLA-DQB1, TNFRSF13C, LINC00926, BIRC3, CD74 (PanglaoDB)

○ (-) CD27

⑱ state 2. switched B cell

○ (+) CD27

○ (-) IgD

⑲ state 3. unswitched B cell

○ (+) CD27, IgD

⑳ state 4. activated B cell

○ (+) CD80, CD86, FAS

⑳ state 5. functional B cell

○ (+) CD27, CCR7, CD197

⑷ A-2. T cell (T lymphocyte)

① pan-T cell

○ (+) CD2, CD3 (CD3D, CD3E, CD3G), KLRC1, TUBA4A, TENT5C, CD274, CYTIP, GPR183, RHOH, SMAP2, ICOS, LAG3, CD47, CCR10, CD58, ITGAE, ITGAL (LFA-1), PTGDR2, IL10, IL13, IL17A, IL2, IL21, IL22, IL25, IL26, IL5, IL9, IGFB1, FOXO4, FOXP1, TBX21, PTPRC (CD45)

○ (+) CD96, SYTL3, RORA, IL7R, CD7, CD2, LEPROTL1, CNOT6L, TRACRUNX3 (Tabula Sapiens)

○ (+) Lcn4, Il7r, Folr4, Cd3d, Tnfsf8, Ms4a4b, Cd3g, Cd40lg, Vipr1, Cxcr6 (Tabula Muris)

○ (+) CCL5, TMSB10, IL32, LOC105874071, GZMA, LOC105858493, LOC105881712, S100A4, NKG7, CRIP1 (Tabula Microcebus)

○ (+) CD3D, CD3G, CD3E, LTB, IL7R, TRBC1, TRBC2, CD7, TRAC, IL32, CXCR4, CD2, CLEC2D, S100A4, LCK, JUNB, CD52 (PanglaoDB)

○ (+) HLA-B, PTPRC, SH2D1A, CD3E, LCK, CD48, ACAP1, GIMAP7, SEPTIN1, CD69, LINC00861, CDC42SE2, CD96, TSTD1, GIMAP4 (SCEVAN)

② class 1. helper T cell (Th)

○ (+) CD4

○ (+) LEF1, TCF7, BCL11B, CAMK4, ITK, IPCEF1, INPP4B, CD6, SCML4, PRKCQ-AS1 (Tabula Sapiens)

○ (+) AC092580.4, OXNAD1, KLRB1, STAT4, CRIP1, SYTL3, PDE4D, RCAN3, CD3G, RORA (Tabula Sapiens)

○ (+) LOC105855976, IL32, RPS27, LOC105874071, IL21, CGA, LRRC31, FOXP3, LOC105873674, GABBR2 (Tabula Microcebus)

○ 1-1. Th1 (helper T cell 1)

○ (+) CD4, CXCR3, IFNγ, IL-2, IL-12, IL-18, STAT4, STAT, TNF, T-Bet, IFNG, GZMB, Tbx21

○ (-) CD8A, CD8B, FOXP3, IL2RA

○ 1-2. Th2 (helper T cell 2)

○ (+) CD4, CCR4, IL-2, IL-4, GATA-3, Gata3

○ (-) CD8A, CD8B, FOXP3, IL2RA

○ 1-3. Th9

○ (+) PU.1, IL-9

○ 1-4. Th17

○ (+) RORγt, IL-17, RORA, RORC, RBPJ, BHLHE40, CCR6, IL23R, Rorc

○ Th17 chemoattraction

○ (+) CXCL16, CCL20

○ 1-5. Th22

○ (+) AHR, IL-22

○ 1-6. Tfh (T follicular helper cell)

○ (+) BCL6, CXCR5, IL-21

○ (+) AL135905.2, CD28, CD5, PBX4, KCNA3, CD7, CCR7, CD6, LSR, RP4-765C7.2 (Tabula Sapiens)

○ 1-7. Effector CD4⁺ T cell

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) TCF7, LEF1, ITK, BCL11B, CITED2, CD3E, CAMK4, IL7R, CD69, SPOCK2 (Tabula Sapiens)

○ (-) SELL,CCR7 (sc-type)

○ 1-8. Memory CD4+ T cell

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, CCR7, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) TRAT1, TRAC, LCK, BCL11B, TCF7, ITK, PIK3IP1, SPOCK2, IL7R, CD3G (Tabula Sapiens)

○ 1-9. metallothionein-expressing T cell: metallothioneins protect cells from oxidative stress and cytotoxicity

○ (+) MT1, MT2

○ 1-10. SRRM2-T cell

○ (+) PNISR, SRRM2

○ 1-11. naïve CD4⁺ T cell

○ (+) CCR7, LEF1

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, CCR7, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) PRKCQ-AS1, CCR7, TXK, TRAC, NOSIP, LCK, TCF7, CCDC109B, BCL11B, PIK3IP1 (Tabula Sapiens)

○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)

③ class 2. cytotoxic T cell (Tc)

○ (+) CD8

○ (+) AC092580.4, CD8A, CD8B, CCL5, GZMA, KLRD1, SYTL3, CD2, CD3G, CD96 (Tabula Sapiens)

○ (+) CCL5, IL32, LOC105881712, LOC105874071, TMSB10, LOC105881288, GZMA, LOC105866296, NKG7, LOC105858493 (Tabula Microcebus)

○ (+) CD2, CD5, CD69, GZMB, TRAC (PanglaoDB)

○ 2-1. cytotoxic T cell (killer T cell)

○ (+) IFNγ (IFNG), TNF, CD8, EOMES, CD8A, CD8B, Thy1.1, KLRG-1, GZMH, PRF1

○ (+) GZMK, CD8A, CD8B, MATK, DUSP5, GZMM, PTPRCAP, CTSW, ZAP70, DUSP2 (Tabula Sapiens)

○ (-) CD4

○ 2-2. CD8-positive alpha-beta effector t cell

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GNLY, CEP78, KLRF1, NKG7, PTGDR, RP11-489E7.4, HIST1H1E, HIST1H1D, SAMD3, GZMM (Tabula Sapiens)

○ (+) GZMK, CD8B, CD8A, DUSP2, GZMM, CCL4, CMC1, CD3E, CCL5, CD69 (Tabula Sapiens)

○ (-) SELL,CCR7 (sc-type)

○ 2-3. memory CD8+ T cell

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, GNLY, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GZMK, SH2D1A, CD8A, CD8B, GZMM, DUSP2, CCL5, GZMA, CTSW, CMC1 (Tabula Sapiens)

○ 2-4. naïve CD8⁺ T cell

○ (+) CCR7

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) LYAR, FGFBP2, GZMH, MYBL1, KLRD1, GZMA, CD8A, CCL5, KLRG1, GNLY (Tabula Sapiens)

○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)

④ class 3. Treg cell (regulatory T cell)

○ (+) CD4, CD25, CD127, CD152, TGFβ, IL-10, IL-12, FOXP3 (FoxP3), STAT5, IL2RA, CTLA4, TIGIT, IL1RL1, ICOS, TNFRSF9

○ (+) FOXP3, RTKN2, TIGIT, CTLA4, IL2RA, IKZF2, BATF, TRBV25-1, SPOCK2, CD28 (Tabula Sapiens)

○ (-) CD8A, CD8B

○ 3-1. naïve regulatory t cell

○ (+) TIGIT, CTLA4, CD5, ABCC1, PTPRCAP, ITK, SPOCK2, IKZF2, LEF1, RP4-765C7.2 (Tabula Sapiens)

⑤ class 4. gamma delta T cell (Tgd cell, γδ-T cell): Compared to alpha beta T cell, a typical cell Typeof T cell. One of innate-like T cells

○ (+) CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, TRDV2, TRGV9, TRGC1, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GNLY, GZMB, FGFBP2, NKG7, PRF1, KLRF1, HOPX, CST7, KLRD1, CTSW, SPON2, GZMA, CD247, CD7, CCL5, TRDC (PanglaoDB)

○ (-) SELL, CCR7 (sc-type)

⑥ class 5. pro-T cell

○ 5-1. DN1 thymic pro-t cell

○ (+) GZMK, CCL4, SOCS1, PRDM1, TRBV25-1, CD2, KLRB1, CCL5, IL7R, TRAC (Tabula Sapiens)

⑦ class 6. DN T(double-negative T cell)

⑧ class 7. MAIT(mucosal-associated invariant T cell): One of innate-like T cells

○ (+) SLC4A10

⑨ state 1. activated T cell

○ (+) CD69, CD25

○ 1-1. early activation

○ (+) GZMK, GZMM, GZMA, NKG7

⑩ state 2. cytotoxic

○ (+) granzyme, perforin

⑪ state 3. naïve

○ (+) CD45RA, CD62L, CCR7, LEF1, SELL, TCF7, IL7R

○ (+) CD3D, SELL, CCR7 (PanglaoDB)

⑫ state 4. memory

○ (+) SELL, CD69, CD247, IL7R, CD3E, GIMAP4, CD2, PTPRC, TCF7, LTB, LCK, TRAC, CD3G, CD3D, TRBC2, CD7 (PanglaoDB)

○ 4-1. effector memory (EM)

○ (+) CD45, CD3, CD4, CD44, CD45RO

○ (-) CD62L, CCR7

○ 4-2. central memory (CM)

○ (+) CD45, CD3, CD4, CD44, CD62L, CD45RO, CD62L, CCR7

⑬ state 5. effector

○ (+) CD45RA

○ (-) CD62L, CCR7

⑭ state 6. experienced

○ (+) INPP5F, GPR25

⑮ state 7. progenitor exhausted

○ (+) TCF1/TCF7, PD-1, TIM-3

⑯ state 8. terminally exhausted

○ (+) Tox/Tox2, PDCD1 (PD-1), TIGIT, HAVCR2, LAG3, CTLA4, ENTPD1

⑰ state 9. immature

○ (+) Rag2, Arpp21, Rag1, A930003A15Rik, Dntt, Syt13, Capn3, Cd8a, Ccr9, Cd8b1 (Tabula Muris)

⑸ A-3. NKT cell (natural killer T-cell)

① (+) CD56, CD3

② class 1. TypeI NKT (iNKT)

○ (+) TCR, Va24, Vβ11

○ (+) CMC1, KLRB1, HIST1H1D, DUSP2, TXK, CD69, CD3E, CITED2, HIST1H1E, AREG (Tabula Sapiens)

③ class 2. TypeII NKT

④ class 3. mature NKT cell

○ (+) KLRF1, PRF1, FGFBP2, GNLY, IL2RB, GZMB, NKG7, SAMD3, CTSW, PYHIN1 (Tabula Sapiens)

○ (+) CCL5, IL32, LOC105874071, RPS27, RPL13A, GZMA, TMSB10, RPS11, LOC105881712, CST7 (Tabula Microcebus)

⑤ class 4. CD4⁺ NKT-like cell

○ (+) CD4, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, COX6A2, ZMAT4, KIR2DL4 (sc-type)

⑥ class 5. CD8⁺ NKT cell

○ (+) CD8, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)

⑹ A-4. natural killer cell (NK)

① pan-NK cell (general NK cell)

○ (+) NCAM1, NCAM2, FCGR3A, CD56, CD94, NKp46, KLRB1, KLRC1, KLRD1, KLRF1, KLRK1, NCR1, FCGR3B, KLRG-1, GNLY, CD244, PRF1, FCER1G, CD247, NK1.1, CCL3, SLAMF6, NCR2, TNFRSF18, LAG3, CD7, NCR3, KIR3DL1, XCL1, CD160

○ (+) Klra8, Gzma, Klra23, Ncr1, Klra18, Ccl5, Gzmb, Cma1, Klra9, Klre1 (Tabula Muris)

○ (+) CCL5, GZMA, LOC105874071, IL32, TMSB10, NKG7, LOC105881712, CST7, LOC105881899, LOC105855163 (Tabula Microcebus)

○ (+) CD56, CD2, CD16, CD94, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, FCGR3A, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)

○ (+) CD69, KLRD1, GNLY, NKG7, IL32, GZMH, CTSW, CCL4, CD2, CCL5, GZMA, GZMB, DUSP2, CST7, CXCR4, S100A4, IL2RG, HOPX (PanglaoDB)

○ (-) CD3D, CD3E, CD3G, CD3Z, CD4, CD8 (sc-type)

② class 1. PB mature NK cell

○ (+) CD16

○ (-) CD56

○ 1-1. cytotoxic

○ (+) Granzyme, Perforin

③ class 2. PB immature / regulatory NK cell

○ (+) CD56, NCR

○ (-) CD16

④ class 3. CD3-negative NK cell: more general

○ (-) CD3

⑤ class 4. CD3-positive NK cell

○ (+) CD3

⑥ state 1. activated

○ (+) CD69

⑦ state 2. immature

(+) SCN1B, SNORD3B-1, RUNX2, CIDEB, TMIGD2, STAC, TNFSF4, BCAS1, PCDH9, TSIX (Tabula Sapiens)

⑺ A-5. nuocyte

⑻ B-1. granulocyte

① pan-granulocyte

○ (+) CD203c, CD15, CD11b, CD63, CD66b, CD123, CD16, CD33, CD117, CD45, Fc-epsilon RI-alpha, CD125, CD13, CD14, CD25, CD44, CD69, CD9, HLA-DR, CCR3, CD116, CD11c, CD193, CD24, CD32, CD43, CXCL8, FCGR3B, MNDA, SIGLEC8, AZU1, MPO, CTSG, LYZ (sc-type)

○ (+) MPO, AZU1, PRTN3, ELANE, MS4A3, CLEC11A, RNASE3, MKI67, TOP2A, UHRF1 (Tabula Sapiens)

○ (+) S100a8, S100a9, Krt81, Ngp, Camp, Lcn2, 1100001G20Rik, Ceacam10, Mmp8, Retnlg (Tabula Muris)

② class 1. basophil: dispersed form of granules

○ (+) MS4A2, FcεR1α, Hgf

○ (+) CD22, CD63,CD203c,CD123,CLC,MS4A3,TCN1,CPA3,HDC,GATA2,MS4A2,IL4,GCSAML,GATA2,TPSAB1 (sc-type)

○ (+) VWA5A, LTC4S, C1orf186, MS4A2, CPA3, TPSB2, HPGDS, TPSAB1, SLC18A2, KIT (Tabula Sapiens)

○ (-) CD19, CD45, CD117

○ 1-1. activated

○ (+) CD63, CD203c

③ class 2. eosinophil: granules form two clumps

○ (+) CD45, CD125, CD193, F4/80, Siglec-8, CD16

○ (+) CD11b, CD193, CD123, CD125, CD15, SIGLEC8, CLC, GATA1, CEBPE, SEMG1, ALOX15, CCL23, PRSS41, PRSS33, THBS4, FOXI1 (sc-type)

④ class 3. neutrophil: granules form three clumps

○ (+) CD11b, CD16, CD18, CD32, CD44, CD55, Ly6G, S100A8, S100A9, CSF3R, CD66b, CD15, SSEA1, NEAT1, CEACAM8

○ (+) CXCR1, CMTM2, MMP25, MGAM, CD177, PADI4, FCGR3B, MMP9, CXCR2, PROK2 (Tabula Sapiens)

○ (+) S100A12, S100A9, S100A8, CAMP, ACTB, LTF, TMSB4X, LCN2, RETN, PGLYRP1 (Tabula Microcebus)

○ (+) CD66b, CD11b, CD15, CD16, CXCL8, FCGR3B, MNDA, CXCR2, MPO, ELANE, PRTN3, MPO, AZU1, LYZ, S100A8, S100A9, PI3, CHI3L1, ANXA3, CXCL1, TGM3, BTNL3, C4BPA, MMP9, CD24, BPI, LTF, GCA, Camp, Ngp, Chil3, Ltf (sc-type)

○ (+) MPO, LYZ, ELANE, S100A8, PRTN3, AZU1, CTSG, SERPINB1, S100A4 (PanglaoDB)

○ 3-1. cd24 neutrophil

○ 3-2. nampt neutrophil

⑤ class 4. mast cell

○ (+) CD32, CD33, CD117, CD203c, FcεR1α, MS4A2, Tryptase, C5ar1

○ (+) CD117, CD203c, CD25, KIT, SLC18A2, CD33, CD32, FCER1A, TPSD1, HPGDS (sc-type)

○ (+) HDC, TPSAB1, TPSB2, CPA3, MS4A2, C1orf186, HPGDS, KIT, SLC18A2, VWA5A (Tabula Sapiens)

○ (+) KIT, CPA3, TPSAB1, IL1RL1, RGS1, HDC, TPSB2, RGS13, MS4A2, VWA5A, HPGDS, DUSP1 (PanglaoDB)

○ (+) CPA3, CMA1, CTSG, SIGLEC6, MS4A2, HDC, PRG2, SLC18A2, TAL1, TPSAB1, SIGLEC8, HPGDS, AMHR2, LAX1, NDST2 (SCEVAN)

○ 4-1. activated

○ (+) CD203c

⑥ class 5. granulocytopoietic cell

○ S100a8, S100a9, Camp, Ngp, Fcnb, Lcn2, Chi3l3, 1100001G20Rik, Cebpe, Ltf (Tabula Muris)

⑼ B-2. dendritic cell (DC)

① pan-dendritic cell

○ (+) IL3RA, CD1C, BATF3, THBD, CD209, CD11C, HLA-DR, CLEC4C, NRP1, FCER1A, CD14, ETV6, CD80, CD86, ADGRE5, IL2RG, LILRA4, CMRF-44, IFNa, BTLA, CADM1, ITGAE, LY75, CLEC4K, CD1B, ITGAM

○ (+) CD86, CPVL, HLA-DPB1, HLA-DPA1, HLA-DQB1, HLA-DMB, HLA-DMA, CXCL16, HLA-DRA, YWHAH (Tabula Sapiens)

○ (+) TMSB4X, CD74, LOC105869751, LOC105872012, CST3, LOC105876793, TMSB10, RPS27, IFI30, LOC105869753 (Tabula Microcebus)

○ (+) S100A9, HLA-DRA, HLA-DQA1, HLA-DMA, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-DPB1, S100A4, CLEC7A, AIF1, LST1, CTSS, PTPRC, FTL, ANXA1, LGALS3, H2AFY, HLA-A, HLA-B, HLA-C (PanglaoDB)

② class 1. activated dendritic cell (aDC)

③ class 2. immature dendritic cell (iDC)

④ class 3. liver dendritic cell

○ (+) HLA-DRB5, SNRPGP14, HLA-DQA1, FCER1A, P2RY6, HLA-DQB1, S100B, RAB7B, CLEC10A, RP11-242C19.2 (Tabula Sapiens)

⑤ class 4. mature conventional dendritic cell

○ (+) IDO2, FSCN1, CCL22, GPR157, TVP23A, IDO1, WFDC21P, TBC1D8, LAMP3, EBI3 (Tabula Sapiens)

⑥ class 5. myeloid dendritic cell

○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C, CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, GPR31, ODF3L1, PRB2, CD207, ARSE, CLEC141, MRC, EBLN1, CRIP3 (sc-type)

○ 5-1. cd1c-positive myeloid dendritic cell

○ (+) MRPS6, C15orf48, KYNU, HLA-DQA2, VMO1, EPB41L3, IL4I1, TFRC, GK, AGPAT9 (Tabula Sapiens)

○ 5-2. cd141-positive myeloid dendritic cell

○ (+) LGALS2, WFDC21P, CPVL, C1orf54, EBI3, BATF3, CLIC2, ADRBK2, HLA-DQA1, FLT3 (Tabula Sapiens)

⑦ class 6. oligodendrocyte

⑧ class 7. plasmacytoid dendritic cell (pDC): A DC subTypethat is rare. This cell is involved in the immune system in blood and produces an excess of interferon 1. pDC secretes IFN-α to activate T cells, but secretes granzyme B to inhibit T cell expansion.

○ (+) SIGLECH, KLK1, HLA-DR, IL3RA (CD123), IRF8, TCF4 (E2-2), SPI1 (PU.1), FLT3L

○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C (BDCA-2), CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, TPM2, LRRC26, ASIP, GPM6B, KRT5, NTM, SCT, SHD, KCNA5, SCARA5, EPHA2, MYMX (sc-type)

○ (+) IRF7, SLC15A4, PLD4, LAMP5, IRF4, RUNX2, GZMB, BCL11A, CHAF1A, ADA (Tabula Sapiens)

○ (+) LILRA4, GPR183, PTCRA, FAM129C, SPIB, GZMB, CXCR4, IRF7, IRF8, JCHAIN, SERPINF1, ITM2C, TCF4, BCL11A, MZB1, DERL3, NRP1 (PanglaoDB)

○ 7-1. activated

○ (+) CD83

⑨ class 8. conventional DC (cDC): One of the innate immune cells.

○ (+) CD11c, HLA-DR, LY75

○ 8-1. cDC1 (excel at cross-presentation)

○ (+) XCR1, CLEC9A

○ 8-2. cDC2

○ (+) CD1C, SIRPα, CLEC10A

○ state 1. activated

○ (+) CD83

⑩ class 9. functoinally defective DC

⑪ class 10. regulatory DC(regDC; tolerogenic DC; tDC)

○ (+) MHC II, CD11b, CD11c, PD-1, B7-H1

○ 10-1. CD83highCCR7+ IL-10DC

○ 10-2. CD83lowCCR7- IL-10DC

○ currently, no clear surface markers are found

⑫ class 11. langerhans-like DC (LanghDC)

⑬ class 12. migratory DC (migDC)

⑭ class 13. AXL+SIGLEC6+ DC (ASDC)

⑽ B-3. macrophage

① pan-macrophage

○ (+) CD11b, CD68, CD163, ADGRE1, ITGAM, CSF1R, CD14, FCGR3A, Cd74, Arg1, CD80, CD86, CXCL5, APOC1, BASP1, FAM49A, GJB2, LPXN, LY86, MAP3K8, MNDA, PLD4, PPARG, SEC24A, SERPINB9, IL1a, IFNb2, CDF, BSF1, BCGF1, TGIF, CSIF, IL13, P600, CSFR, CLEC13D, M130, PDL2, B7DC, RETNLB, CCR2, CSF1, CLEC6A, ITGB2, PDCD1LG2, CSF2, LYZ, PLAUR, LST1

○ (+) MARCO, ACP5, OLR1, PLTP, SLCO2B1, MS4A4A, C1QC, MSR1, FBP1, MRC1 (Tabula Sapiens)

○ (+) Cd300c, Siglech, Apol7c, Gm8221, H2-M2, Cox6a2, Lilra5, Atp2a1, Cd209g, Cd209f (Tabula Muris)

○ (+) FTL, FTH1, LOC105882215, CD74, TMSB4X, APOE, CST3, LOC105869751, C1QA, SPP1 (Tabula Microcebus)

○ (+) CD68, CD163, CD14, CD11b, CD206, CD80, CD86, CD16, CD64, CCL18, CD115, CD11c, CD32, HLA-DR, MRC1, MSR1, GCA, Pf4 (sc-type)

○ (+) ITGAM, FCGR3A, LILRB4, TREM2, CXCL16, CD83, RBPJ, GPNMB, VSIG4, MS4A4A, C5AR1, CCL2, S100A4, NRP2, CD36, MS4A7, CLEC7A, CD74, CSF1R, LGALS3, CYBB, ITGAX, TYROBP, DAB2, MAF, AIF1, CYP27A1, SLC7A7 (PanglaoDB)

○ (+) CD68, CD163, MS4A4A, CYBB, FCER1G, CLEC5A, MS4A6A, HK3, MSR1, IGSF6, CHIT1, DNASE2B, FDX1, SLAMF8, VSIG4 (SCEVAN)

○ (-) CD56, CD11c

② class 1. M1 macrophage

○ (+) iNOS, IL-6, CD86, CD80, CD68, MHCII, IL-1R, TLR2, TLR4, SOCS3, ITGAX (CD11c), CD16, FCN1, HLA-DR, pSTAT1, IL-12, MHC-II, CD80, 27E10, CCL2, S100A8, S100A9, CXCL9, CXCL10

③ class 2. M2 macrophage

○ (+) MRC1, CD163, CD204, CD206, VEGF, cMAF, ARG1, YM1, CCL20, CCL22, 1IDO1

○ 2-1. M2a

○ (+) CD163, SR, CD206, CD200R, TGM2, DecoyR, IL-1R II, Fizz1, Arginase-1, MHCII

○ 2-2. M2b

○ (+) CD86, MHCII

○ 2-3. M2c

○ (+) CD163, TLR1, TLR8

○ 2-4. M2d

○ (+) VEGF

○ 2-5. TAM

○ (+) CCL2, CD3, CD31, CD68, CD163, HLA-DR, iL-10, iNOS, PCNA, VEGF

○ 2-6. TCR-positive

○ (+) CD68, Fyn, LAT, Lck, ZAP70

○ 2-7. CD169-positive

○ (+) CD11b, CD11c, CD68, F4/80, MHCII

④ class 1. bone-marrow-derived macrophage (BMDM)

⑤ class 2. dust cell

⑥ class 3. Kupffer cell

○ (+) CD14, CD68, TNF, LYZ, MPO, VSIG4, PROK2, STARD5, MSR1, PPARA, TREM1, SLC11A1, MMP13, VDR, CHIT1, OSM, PPARD, CLEC4F, ADGRE1, IL1B, SLC40A1, G6PD, TIMD4, MNDA, SLC15A3, DNASE1L3, MARCO, HFE, CD38, CD163, CCR5, CLEC1B, CLEC4G, GPIHBP1, FOLR2, PLTP, FTL, IRF7, SPIC, CSF1R, C1QC, C1QA, C1QB, CLEC4E (sc-type)

○ (+) CLEC4F, ID3, ZEB2, LXRα

⑦ class 4. microglial cell

○ (+) BHLHE41, SLC2A5, HAMP, FCGR1A, SLC1A3, AP1B1, B3GNT5, HAVCR2, LILRB4, CSF1R (Tabula Sapiens)

○ (+) NAIP, CX3CR1, P2RY12, CCR1, FGD2, FCGR2A, DOCK8, TREM2, FOLR2, ADAM28, C1QC, P2RY13, C1QA, CD68, C1QB (SCEVAN)

○ 4-1. eye microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1, CX3CR1, CX3CL1 (sc-type)

○ 4-2. brain microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)

○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1

⑧ class 5. splenocyte

⑨ class 6. immunosuppressive macrophage

○ (+) CD163, MSR1

⑩ class 7. TIM4+ perivascular macrophage

○ (+) TIM4, LYVE1, FOLR2, cMAF

○ (-) MHCII

⑪ class 8. MHCII+ Perivascular Macrophage

○ (+) MHCII, cMAF

○ (-) TIM4, LYVE1

⑫ state 1. aged macrophage

○ (+) Cd274, Clec4d

○ (-) Coro1a

⑾ B-4. monocyte

① (+) CD14, FCGR1A, CD68, S100A12, NR4A1, CD4, CD11C, HLA-DR, SPI1, NCF2

② (+) FOLR3, TCIRG1, RP11-1143G9.4, RNASE2, SULT1A1, FCN1, CD300E, PRAM1, ARHGAP4, C19orf38 (Tabula Sapiens)

③ (+) Lyz2, Lyz1, Galnt9, Ms4a8a, Apoc2, Gm9733, Ms4a6c, Ccr2, Ccl9, Ccl6 (Tabula Muris)

④ (+) FTH1, SOD2, TMSB4X, CCL15, LGALS1, CD74, S100A4, PGLYRP1, CXCL8, FTL (Tabula Microcebus)

⑤ (+) OAS1, IRF7, PLSCR1, MX1, HLA-DRA, IFIT1, IFIT3, TNFSF10, S100A9, S100A4, CD44, PTPRC, PSAP (PanglaoDB)

⑥ (-) CD206, CD86

⑦ class 1. classical monoctye (C monocyte)

○ (+) CD14, S100A8, S100A9

○ (+) CD14, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, VCAN, S100A12, CXCL8, S100A8, S100A9, LYZ, CST3, Elane1 (sc-type)

○ (+) FLT3, TMEM170B, IFI30, RNASE2, FCN1, ADAMTS2, EMILIN2, CD33, SH3BP2, SLC43A2 (Tabula Sapiens)

○ (-) CD56, CD16 (=FCGR3A) (sc-type)

⑧ class 2. non-classical monocyte (N monocyte)

○ (+) FCGR3A (CD16), CDKN1C, MTSS1

○ (+) CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, FCGR3A, CDKN1C, LST1, FCER1G, MS4A7, RHOC, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)

○ (+) LRRC25, CSF1R, LILRB2, FCGR3A, CD86, LST1, MS4A6A, CLEC7A, C3AR1, MS4A4A (Tabula Sapiens)

○ (-) CD14

○ (-) CD56 (sc-type)

⑨ class 3. intermediate monocyte (I monocyte)

○ (+) CD14, CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, IL1B, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)

○ (+) FBXL5, BID, CD300E, FGL2, MPEG1, RNASE2, C3AR1, LILRB2, CYBB, MS4A6A (Tabula Sapiens)

○ (-) CD56 (sc-type)

⑿ B-5. class 1. MDSC(myeloid-derived suppressor cell)

① (+) Gr-1, CD11b

② class 1. eMDSC(early-stage MDSC)

○ (+) CD33

○ (-) HLA-DR, Lin

③ class 2. PMN-MDSC (polymorphonuclear MDSC)

○ (+) ITGAM (CD11b), CD33, CD15, CEACAM8 (CD66b), Ly6G

○ (-) CD14, Ly6C, HLA-DR

○ (low) Ly6C

④ class 3. M-MDSC (monocytic MDSC)

○ (+) ITGAM (CD11b), CD33, CD14

○ (-) HLA-DR, CD15, Ly6C, Ly6G

○ (low) HLA-DR

○ (high) Ly6C

⒀ B-6. Monoblast

⒁ B-7. Promonocyte

⒂ Category II. erythrocyte (erythroid, red blood cell)

① (+) Hbb-bt, Hbb-bs, Hba-a2, Hba-a1, Car2, GATA1, E2f2, Fam46c, Slc25a37, Tfrc, Tmod1

② (+) ALAS2, HBQ1, HBM, EPB42, HBB, HBD, HBA1, HBA2, SLC4A1, TRIM58 (Tabula Sapiens)

③ class 1. erythroblast

④ class 2. erythroid-like and erythroid precursor cells

○ (+) ALAS2, HBB, HBA1, HBA2, GYPB, AHSP, HBM, FECH, BPGM, HBD, HEMGN, HMBS, NCOA4, SLC4A1, SLC25A39, SLC25A37, EPB42,GYPC, SNCA (PanglaoDB)

⑤ class 3. reticulocyte

⒃ Category III. megakaryocytes: platelet production in bone marrow

① (+) CD61, CD41, CD42b, CD41a, CD42a, CXCR4, CD110 (sc-type)

② class 1. platelet

○ (+) CD41, CD42b, CD61, CD31, PPBP, PF4, GNG11, SDPR, CLU, CD41, CD110 (sc-type)

○ (+) RUFY1, NRGN, LY6G6F, PRKAR2B, MTURN, MMD, TSPAN33, PF4, CTSA, GP9 (Tabula Sapiens)

○ (+) CCL5, ITGA2B, PF4, F13A1, GP9, NCOA4, RGS18, PPBP, TREML1, CD9, NRGN, OST4, SPARC, GPX1, CAVIN2, PPDPF, MYL9, MAP3K7CL, GNG11, GRAP2, MPIG6B, ARHGDIB, CDKN2D, HLA-A, PDLIM1, SRGN (PanglaoDB)

⒄ Category IV. progenitor

① common lymphoid progenitor (CLP)

○ (+) CD34, CD38, CD10, CD45RA

② common myeloid progenitor (CMP)

○ (+) CD34, CD38, CD135

○ (+) RP11-620J15.3, PRSS57, DPPA4, CYTL1, GATA1, KLF1, RP11-354E11.2, AC002454.1, MYB, SPTA1 (Tabula Sapiens)

○ (-) CD7, CD10, CD45RA, CD90/Thy1

③ early progenitor

○ (+) Epha5, Tcf4, Erbb4

④ erythroid lineage cell

○ (+) GMPR, SLC25A39, HBA2, HBA1, HBB, HBQ1, SNCA, HBD, ALAS2, CA1 (Tabula Sapiens)

○ (+) LOC105883507, LOC105856254, AHSP, GPX1, PRDX2, LOC105856252, CA2, LOC105856255, RPS12, BLVRB (Tabula Microcebus)

⑤ erythroid progenitor

○ (+) Ter119, Abcb4, Ammecr1, Myh10, Podxl, Tmem56

○ (+) FAM178B, RHAG, KLF1, SPTA1, GATA1, GFI1B, KCNH2, KEL, RP11-620J15.3, CA1 (Tabula Sapiens)

○ (+) LOC105883507, RPS18, RPS12, ZC3H10, RPLP1, RPL13, RPS20, RPS5, RPL10, RPS14 (Tabula Microcebus)

○ (+) PTPRC, GYPA (CD235a), RUVBL1, TFRC (CD71), FOLR1, CD36, ITGA4, HBB, CD235a, HBD, CA1 (sc-type)

⑥ granulocyte-monocyte progenitor (GMP)

○ (+) CD34, CD38, CD45RA, CD123, CD135

○ (-) CD10

⑦ hematopoietic stem cell (HSC)

○ (+) CD34, CD45, CD49, CD90/Thy1, Cd150, Vcam1

○ (+) PRSS57, AVP, CRHBP, DPPA4, PINK2, CYTL1, MYB, KIAA0125, MLLT3, RP11-620J15.3 (Tabula Sapiens)

○ (+) Ctsg, Mpo, Prtn3, Elane, Nkx2-3, Ms4a3, Kcnk12, Prss57, Muc13, Bex6 (Tabula Muris)

○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31, Nestin, OCT4, CD117, KDR, CXCL8, AVP, CRHBP, ALDH1A1, CD49, CD90, CD69, CD24, CD45RA, Keratin-19, ASPM, CD10, CD123, ABCG2, CD135, CD49f, EpCAM, Keratin-7, SCA-1, CD14, CD150, CD271, HLA-DR (sc-type)

○ (-) CD45RA, Cd127, Cd135, PTPRC, CD38

⑧ megakaryocyte–erythroid progenitor (MEP)

○ (+) CD34, CD38

○ (-) CD7, CD10, CD45RA, CD135, IL3Rα

⑨ mesenchymal stem cell (MSC)

○ (+) VIM (vimentin), Vim

○ (+) THBS4, SMOC2, LINC01088, BMPER, GFRA1, PQLC2L, CILP, LAMA2, NEGR1, VGLL3 (Tabula Sapiens)

○ (+) Ifi205, Ptx3, Ccl11, Lrrn4cl, Saa1, Tnfaip6, Scg3, Stmn4, D630033O11Rik, Mt2 (Tabula Muris)

○ (+) GSN, DCN, LOC105866476, APOD, IGFBP3, JUNB, LOC105866554, EGR1, FOS, CHIT1 (Tabula Microcebus)

○ Class 1. mesenchymal cell

○ (+) Hao1, 3110079O15Rik, Ucma, Col9a1, Wif1, Mia1, Hapln1, Lect1, Clec3a, Acan (Tabula Muris)

⑩ multi-potent progenitor (MPP)

○ (+) CD34

○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31, Nestin, OCT4, CD117, KDR, CXCL8, AVP, CRHBP, ALDH1A1, CD49, CD90, CD69, CD24, CD45RA, Keratin-19, ASPM, CD10, CD123, ABCG2, CD135, CD49f, EpCAM, Keratin-7, SCA-1, CD14, CD150, CD271, HLA-DR (sc-type)

○ (-) CD45RA, CD90/Thy1, PTPRC, CD38

⑪ plasmablast

○ (+) Cd38, MHC class II, CD27, CD38, CD80,

○ (+) ZNF587P1, CTD-2031P19.4, MTND5P11, AC074289.1, ZWINT, RP11-380M21.2, CDC42P6, PHTF1, RNU4-1, CEP128 (Tabula Sapiens)

⑫ progenitor cell

○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31 (PECAM1), Nestin, OCT4, CD117, KDR, AVP, CRHBP, ALDH1A1, STMN1, CD38, PTPRC, CD135 (sc-type)

⒅ tissue 1. PBMC(peripheral blood mononuclear cell)

⒆ tissue 2. BALF(bronchoalveolar lavage fluid)

⒇ tissue 3. tumor

① tumor infiltrating lymphocyte (TIL)

○ (+) CD45, CD3

⒇ tissue 4. pancreatic immune cell

① immune system cell

○ (+) MS4A1, CD19, CD4, CD8A, CD7, CTLA4, CD27, CCR7, CYTIP, IGHD, CD38, IL2RA, ISG20, SELL, IL7R, FOXP3, IGKC, IGLC3, IGLC2, CD79A, CD68, CD163, CD14, ITGAM, MRC1, MS4A7, CD3D, CD3E, CD3G (sc-type)

② mast cell

○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)

③ mesenchymal cell

○ (+) ITGB1, NT5E, THY1, ENG, KIT, ALCAM (sc-type)

④ pancreatic progenitor cell

○ (+) ONECUT1, PDX1, PTF1A, CXCR4, ISL1, NKX2-2, EPAS1, ARX, NEUROG3, SOX9, RPL23A, CTNNB1, YAP1, RGS16, MFNG (sc-type)

⑤ pancreatic stellate cell

○ (+) TIMP1, RGS5, SPON2, GEM, DYNLT1, PDGFRB, KRT10, CYGB, CCN2, MMP14, NDUFA4L2, PDGFRA, INHBA, TGFB1 (sc-type)

○ (+) SNRPE, FAM162B, CDK4, NGFR, SEPT4, PTH1R, HEYL, ARHGAP42, ARHGEF17, SYDE1 (Tabula Sapiens)

○ (+) TIMP1, SPON2, GEM, DYNLT1, PDGFRB, KRT10, MMP14, NDUFA4L2, COL6A1, FN1, COL4A1, COL6A2, MGP, COL3A1, SPARC, COL1A1, TIMP3, TNFAIP6, COL1A2, SFRP2, COL6A3, THY1 (PanglaoDB)

⑥ peri-islet Schwann cell

○ (+) MPZ, EGFL8, GFRA1, OLFML2A, GULP1, SLITRK6, VGLL3, GFRA3, INSC, SLITRK2, FIGN, LRRTM1, SEMA3B, NGFR, PNLIPRP1, GFRA2 (sc-type)

○ (+) MPZ, OLFML2A, GULP1, GFRA3, INSC, SLITRK2, FIGN, SEMA3B, NGFR (PanglaoDB)

⒇ tissue 5. liver immune cell

① immune system cell

○ (+) CD19, MS4A1, IL2RA, PTPRC, CD4, CD8A, CD3D, CD3E, CD3G, CD11c, CD14, CD16, CD56, CD16, CD42b, CD7, CD8, IgD, CD38, CD24, CD20, CD14, CD16, HLA-DR, CD11b, CD11c, CD123, CD15, CD33, CD66b, CD27, CD94, CD45 (sc-type)

② Kupffer cells

○ (+) CD14, CD68, TNF, LYZ, MPO, VSIG4, PROK2, STARD5, MSR1, PPARA, TREM1, SLC11A1, MMP13, VDR, CHIT1, OSM, PPARD, CLEC4F, ADGRE1, IL1B, SLC40A1, G6PD, TIMD4, MNDA, SLC15A3, DNASE1L3, MARCO, HFE, CD38, CD163, CCR5, CLEC1B, CLEC4G, GPIHBP1, FOLR2, PLTP, FTL, IRF7, SPIC, CSF1R, C1QC, C1QA, C1QB, CLEC4E (sc-type)

○ (+) CLEC4F, ID3, ZEB2, LXRα

③ liver progenitor cell

○ (+) KRT7, KRT19(sc-type)

④ mast cell

○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)

⑤ mesenchymal stem cell

○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)

⑥ monocyte

○ (+) FCGR3A, FCGR3B, CD14, Elane1 (sc-type)

⑦ macrophage

○ (+) Abcc3, Adgre1, Itgam, Mertk, Mrc1, Sdc3

⑧ myeloid

○ (+) Cd34, Rassf4

⑨ neutrophil

○ (+) Arsb, B4galt6, Gca, Olr1, Sgms2

⒇ tissue 6. eye immune cell

① microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1, CX3CR1, CX3CL1 (sc-type)

② eye immune cell

○ (+) CD25, CD69, CD4, CD3, ITGAM, C1qa, Fcer1g, CD19, CD20, Trac, Ltb, Cd52, Trbc2 (sc-type)

⒇ tissue 7. kidney immune cell

① immune cell

○ (+) CD19, IGHA2, IGHG3, IGHM, IGKC, JCHAIN, CD40, CD79A, CPNE5, FCRL5, HLA-DRA, IGHA1, IGHG1, IGHG2, IGKV1-12, IGLC2, IGLC3, IGLC7, IGLL5, MS4A1, MZB1, PKHD1L1, PNOC, POU2AF1, TNFRSF13C, CD3D, TRAC, IL7R, CD3E, CD8A, TRBC2, CD52, FCGR3A, IL32, KLRD1, CD68, CXCL8, FCGR3B, MNDA, KIT, PTGS2, SLC18A2, Trac, Ltb, Cd52, Trbc2, Shisa5 (sc-type)

② hematopoietic cell

○ (+) CORO1A, MNDA, SRGN, HLA-DPA1, LST1 (sc-type)

⒇ tissue 8. brain immune cell

① immune system cell

○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)

② microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)

○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1

⒇ tissue 9. lune immune cell

① alveolar macrophage

○ (+) HLA-DR, CD169, CD206, SIGLECF, CD11c, PPARγ, C/EBPβ

○ (+) FTH1, FTL, TMSB4X, TYROBP, C1QA, RPLP1, LGALS3, CTSD, ACTB, RPS18 (Tabula Miceocebus)

○ (+) ABCG1, CCL3, CD36, CLEC7A, CSF2RB, CXCL2, G0S2, GAL, GDA, GNGT2, GPNMB, IL18, IL1B, ITGAX, KLHDC4, MARCO, MCEMP1, MPP1, MRC1, OLR1, PLET1, S100A4, TLR2, TNFAIP2, TRIM25 (sc-type)

② interstitial macrophage

○ (+) HLA-DR, CD206

○ (-) CD169

③ immune system cell

○ (+) ADGRE1, ARG1, BIRC5, CCL17, CCL18, CD14, CD163, CD19, CD22, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD68, CD74, CD80, CD83, CD86, CD8A, CD8B, CDCA3, CDK1, CEBPE, CR2, CSF1R, EAF2, FCER2, FCGR3A, FLT3, GIMAP3P, HLA-DRA, HMMR, IGHM, IL2RA, ITGAE, ITGAM, ITGAX, LAX1, MS4A14, MZB1, NRP1, NUSAP1, PAX5, PRG2, PTPRC, SLPI, THBD, TNFRSF17, TRBC1, XCR1 (sc-type)

⒇ tissue 10. adrenal immune cell

① myeloid cell

○ (+) MS4A14, LILRA1, RP11-554D14.6, AC007040.8, MS4A7, RP11-489O18.1, CLEC10A, MS4A4A, RN7SL138P, CD163, CD14, SIGLEC1, VSIG4, CLEC7A, LILRA2 (sc-type)

② erythroblast

○ (+) TPSAB1, CTD-2008P7.9, RP11-85G21.3, CTSE, CTA-392E5.1, EIF5AP2, CTA-363E6.6, C17orf99, SLC4A1, TRIM10, MIR144, ART4, AHSP, GYPA, HBM (sc-type)

③ lymphoid cell

○ (+) GZMH, XCL1, KLRC3, RP11-94L15.2, GZMA, IL2RB, TRAT1, SH2D1A, DTHD1, CD3E, ZNF831, GNLY, PRF1, IGHD, THEMIS (sc-type)

⒇ tissue 11. heart immune cell

① lymphoid cell

○ (+) GZMB, FCRL2, KLRC2, XCL1, LINC00861, PRF1, CD3G, SH2D1B, ANTXRLP1, VPREB3, SH2D1A, CRTAM, CXCR6, RP11-94L15.2, GZMK (sc-type)

② myeloid cell

○ (+) XCR1, TMPRSS4-AS1, TIMD4, PRTN3, MMP9, CD86, CLEC5A, SIGLEC1, CLEC7A, C1QC, P2RY13, FCN1, CSTA, CD300LF, MS4A6A (sc-type)

③ erythroblast

○ (+) RP5-857K21.7, CENPW, SLC46A1, GSPT2, RHCE, SLC7A11, P2RX6, SKA1, FARSA, ZNF90, TMCC2, RP11-225B17.2, TMEM161A, ZNF583, ENPP4 (sc-type)

⒇ tissue 12. intestine immune cell

① erythroblast

○ (+) AHSP, SPTA1, HBG2, HBA2, HBM, HBG1, HBA1, SLC4A1, HBB, GYPA, HEMGN, HBZ, ALAS2, MIR144, MYL4 (sc-type)

② myeloid cell

○ (+) VSIG4, RPL32P1, CD207, AP000439.1, HCAR3, C5orf20, AC010492.4, P2RY13, LILRB2, LILRB5, IL1B, C1QB, CD163, C1QC, DNASE1L3 (sc-type)

③ lymphoid cell

○ (+) IL17A, ICOS, SH2D1A, GZMK, RP11-553L6.2, TRGC1, RP11-104L21.3, TRDC, GZMA, VPREB1, CCR4,LTA, NCR2, CD247, RP11-94L15.2 (sc-type)

⒇ tissue 13. muscle immune cell

① class 1. erythroblast

○ (+) RHAG, GYPA, AHSP, GYPB, HBZ, ALAS2, SLC4A1, SLC14A1, EIF5AP2, HBM, HBA1, EPB42, RP11-57H12.2, ALS2CR12, SLC25A37 (sc-type)

② class 2. myeloid cell

○ (+) FCN1, MS4A4E, TMPRSS4-AS1, CD86, FLT3, P2RY13, IL10RA, FOLR2, MNDA, HLA-DQB1, MS4A4A, AMICA1, CYTH4, MS4A6A, CFP (sc-type)

③ class 3. lymphoid cell

○ (+) IL7R, CD8A, NKG7, CD247, NCR1, RP11-61O1.1, TRAC, CD3E, ITK, CD2, MATK, RP11-444A22.1, SYTL1, IL2RB, GZMA (sc-type)

⒇ tissue 14. placenta immune cell

① class 1. lymphoid cell

○ (+) IGJ, IGHM, KLRC3, GZMH, PTGDR, IGHGP, IKZF3, IFNG-AS1, TIGIT, KLRC2, LCK, ANKRD36BP2, TNFRSF18, IGHG3, LINC00861 (sc-type)

② class 2. myeloid cell

○ (+) SIGLEC10, RP11-1143G9.4, LYZ, ADAMDEC1, LILRB2, HLA-DRB5, SDS, HLA-DOA, SIGLEC1, MMP9, LILRB4, C1QB, TLR2, TLR7, S100A8 (sc-type)

⒇ tissue 15. spleen immune cell

① class 1. lymphoid cell

○ (+) RN7SL337P, KLRC4-KLRK1, RP11-553L6.2, RP11-861A13.4, RP11-38J22.6, ZNF860, RP11-693J15.5, RP11-61O1.1, FCRL3, CTD-2215E18.1, RP5-1028K7.2, IKZF3, LINC00861, IL9RP3, VAV3-AS1 (sc-type)

② class 2. myeloid cell

○ (+) CLEC9A, RP11-489O18.1, RP3-522P13.3, RP11-807H22.7, RP11-1080G15.1, FCN1, EMR4P, TMPRSS4-AS1, RP11-157G21.2, CSF2RA, OSCAR, RP3-522D1.1, CD163L1, RUFY4, DLEU7-AS1 (sc-type)

③ class 3. erythroblast

○ (+) HDC, PRSS57, EIF5AP2, PPAPDC1A, MTL5, CTA-392E5.1, ACSBG1, RP5-964N17.1, GYPA, SLC25A21, RP11-146I2.1, MIR144, SLC2A14, CTA-363E6.6, SLC4A1 (sc-type)

④ class 4. white pulp macrophage

○ (+) CD68

○ (-) F4/80

⑤ class 5. marginal zone macrophage

○ (+) SIGN-R1, LXRα

⑥ class 6. red pulp macrophage

○ (+) VCAM1, Spi-C

○ (-) CD11b

⒇ tissue 16. stomach immune cell

① class 1. erythroblast

○ (+) KLF1, SLC4A1, HBM, NFE2, HBZ, GYPB, HBG2, HBB, ALAS2, SPTA1, HBA1, HEMGN, RNF224, HBG1, HBA2 (sc-type)

② class 2. myeloid cell

○ (+) C1QC, HLA-DQB1, MS4A6A, CD14, C1QB, CD163L1, IGSF6, CCDC26, C1QA, NCF2, HLA-DRB1, HLA-DRB5, CLEC7A, MS4A7, HLA-DPA1 (sc-type)

③ class 3. lymphoid cell

○ (+) ICOS, CD27, NKG7, CD28, CD3D, CHI3L2, TRAT1, THEMIS, CD52, KLRB1, CD79B, CCL5, TRBC2, SIRPG, CD3E (sc-type)

⒇ tissue 17. thymic immune cell

① class 1. antigen presenting cell

○ (+) IL1RN, EBI3, FGD2, MCOLN2, MMP9, TLR10, LINC00996, CD80, CXCL10, SLAMF7, P2RY13, SLC24A4, HCK, C1QB, LYZ (sc-type)

⒇ tissue 18. bladder immune cell

① class 1. B cell

② class 2. macrophage

③ class 3. mast cell

④ class 4. NK cell

⑤ class 5. plasma cell

⑥ class 6. plasmacytoid dendritic cell

⑦ class 7. T cell

5. Type 4. stromal cell

⑴ pan-stromal cell

① (+) Slc7a10, Slc38a5, Slc36a2, Adrb3, Scn3a, C7, Prkg2, A330076H08Rik, Inmt, Foxf2 (Tabula Muris)

② (+) DCN, PAPPA, SFRP4, THBS2, LY86, CXCL14, FOXF1, COL10A1, ACTG2, APBB1IP, SH2D1A, SULF1, MSR1, C3AR1, FAP (SCEVAN)

⑵ tissue 1. connective tissue

① Overview

○ (+) ADAMTS5, COL5A2, GPSM2, ITGBL1, TNXB, GPR133, CHRDL1, NBL1, SEMA3C, ELN (Tabula Sapiens)

② class 1. adipocyte

○ (+) ADH1B, ADIPOQ, ANKRD29, CAVIN2, CLEC14A, EGFL7, HOXD8, HOXD9, KDR, LPL, MMRN2, NOSTRIN, PDCD1LG2, PDE4A, RAMP2, RAPGEF3, SOX18, TFAP2A, TIMP4, UCP1

○ (+) STAT6, TFE3, APPL2, APOL6, PXMP2, CAVIN1, MMP2, COL6A2, MT2A, TIMP1, METRN, METRNL, MYO1C, NQO1, SYAP1, CRNDE, TSPO, LRP1, HOXC9 (PanglaoDB)

③ class 2. preadipocyte

④ class 3. chondrocyte

○ (+) Sox9, Col2a1

○ 3-1. columnar chondrocyte

○ (+) Sulf1, Robo1

○ 3-2. early hypertrophic chondrocyte

○ (+) Runx2, Ibsp

○ 3-3. late hypertrophic chondrocyte

○ (+) Spp1, Mmp9

○ 3-4. nucleus pulposus cells

○ (+) Pax1, Fmod

○ 3-5. prehypertrophic chondrocyte

○ (+) Prrx1, Fbxl7

○ 3-6. round chondrocyte

○ (+) Sox5, Sox9

⑤ class 4. fat cell

○ (+) GABRA4, SCD, CIDEA, PNLIPRP3, AWAT2, ACSBG1, KRT79, LCN1, GLDC, FAR2 (Tabula Sapiens)

⑥ class 5. fibroblast

○ (+) DCN, PRELP, RGS5, ACTA2 (α-SMA), PDGFRB (PDGFRβ), CD29, FAP, FSP1, CAV1(caveolin 1), Apod, Apoe, IGF1, MMP1, MMP12, PIM1, TAC1, TCEAL7, FBLN2, Fgr, Ccr2, Ccbe1, MMP11, COL12A1

○ (+) CD248, SFRP2, COL1A1, GAS1, CCDC80, PCOLCE2, ISLR, COL5A1, PLA2G2A, FBN1 (Tabula Sapiens)

○ (+) DCN, APOD, CFD, MGP, GSN, APOE, FBLN1, LGALS1, MMP2, LUM (Tabula Microcebus)

○ (+) LUM, COL6A2, MMP2, IGFBP6, CDH11, COL6A3, C1S, RARRES2, SPON2, CTGF, COL1A2, COL3A1, VIM, FSTL1, GSN, SPARC, S100A4, COL1A1, MGP, SERPINH1, DCN, EGR1, FOSB, KLF6, STAT3, CXCL14 (PanglaoDB)

○ (+) AMOTL2, DPT, ISLR, SVEP1, FGF7, ELN, TCF21, ASPN, COL14A1, PRDX4, S1PR2, C7, COL6A3, MMP2, VIM (SCEVAN)

○ 5-1. activated fibroblast

○ (+) COL1A1, COL1A2, COL3A1, COL22A1, FAP, NOX4, POSTN, THBS4, NNMT, COL5A1, SPP1, FN1, CTHRC

○ 5-2. alveolar fibroblast

○ (+) MGP, APOD, APOE, DCN, JUN, CTGF, FOS, MFAP4, SELENOP, JUNB (Tabula Microcebus)

○ 5-3. cancer-associated fibroblast (CAF)

○ (+) FAP, THY1, FST1, BGN, DCN, COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, COL6A3, CD90.2, FSP1

○ (-) CD45

○ 5-3-1. CAF-S1 (immunosuppressive function)

○ 5-3-1-1. myCAF (myofibroblastic)

○ (+) NDUFA4L2, MAP1B, SPARCL1, RGS5, TPPP3, MCAM

○ (+) HSD17B2, TCF21, FOXF1, NR2F1, PDPN, PLAT, EMILIN1, PDGFRA, APCDD1, CYGB (Tabula Sapiens)

○ (+) APOD, APOE, MGP, COL1A2, LGALS1, DCN, COL1A1, TAGLN, FBLN1, CFD (Tabula Microcebus)

○ Type 1. ecm-myCAF

○ (+) LRRC15, GBJ2

○ Type 2. TGFβ-myCAF

○ Type 3. wound-myCAF

○ Type 4. IFNαβ-myCAF

○ Type 5. acto-myCAF

○ 5-3-1-2. iCAF (inflammatory)

○ Type 1. detox-iCAF

○ (+) ADH1B, GPX3

○ Type 2. IL-iCAF

○ Type 3. IFNγ-iCAF

○ 5-3-2. CAF-S2

○ 5-3-3. CAF-S3 (abundant in healthy tissue)

○ 5-3-4. CAF-S4 (pro-metastatic function)

○ 5-3-5. CAFap (antigen-presenting CAF)

(+) ACTA2, HLA-DRA, CD74

○ 5-4. fibroblast of breast

○ (+) ARSG, THBS2, JHDM1D-AS1, CLMP, RSPO3, TWIST1, MMP3, LOX, FRMD4A, SLC7A2 (Tabula Sapiens)

○ 5-5. fibroblast of cardiac tissue

○ (+) CDH19, CRLF1, FMOD, FAIM2, ADAMTSL2, ABCA6, PRELP, MATN2, PLEKHH2, FIBIN (Tabula Sapiens)

○ 5-6. myofibroblast

○ (+) ACTA2, CDH11, CTHRC1

⑦ class 6. goblet cell

○ (+) TFF3, FCGBP, STARD10, TSPAN1, CKB, MUC4, GOLM1, TMC5, PIGR, SLC26A2 (Tabula Sapiens)

⑧ class 7. limbal stromal cell

⑨ class 8. melanocyte

○ (+) MIA, TYR, SLC45A2, CDH19, PMEL

○ (+) TYR, MITF, TRPM1, MLANA, TYRP1, DCT, BCAN, PMEL, CHCHD6, GPR143 (Tabula Sapiens)

⑩ class 9. spindle cell

⑶ tissue 2. muscle cell

① (+) CMSS1, MT1A, AXL, SLC7A2, PHLDB2, ADAMTS4, KCNE4, VASN, TWIST1, MTHFD2 (Tabula Sapiens)

② class 1. bronchial smooth muscle cell

○ (+) ENAH, PDLIM7, NTRK3, RASL12, DES, AOC3, GUCY1B3, C2orf40, CASQ2, ACTG2 (Tabula Sapiens)

③ class 2. cardiac muscle cell (cardiomyocyte)

○ (+) Myh6, Myh7, Tnnc1

○ (+) MYH6, TECRL, COL2A1, AC020909.2, NKX2-5, FBN2, TNNT2, MYL4, MYL7, ACTC1 (Tabula Sapiens)

○ (+) RP11-439H8.4, RNA5SP327, CTD-2552K11.2, Y_RNA, AC018464.3, HHATL, BMP10, RP11-461A8.4, UGT2B4, PRSS42, WI2-1896O14.1, FABP2, EPN3, RP11-406O23.2, AC009878.2 (sc-type)

④ class 3. skeletal muscle cell

○ (+) RP11-755O11.2, ASB15, RP11-456H18.2, RPL7P3, PVALB, RN7SL365P, RP11-432J24.5, C8orf22, ASB10, RP5-921G16.2, CLDN9, RP5-1039K5.13, AC137723.5, RP11-255G21.1, AC093063.2 (sc-type)

○ 3-1. myoblast

○ 3-2. myocyte

○ 3-3. satellite cell

○ (+) Sds, Myod1, Chrdl2, Asb5, Fam132b, Popdc3, Chodl, Ank1, Gdnf, Des (Tabula Muris)

⑤ class 4. fast muscle cell

○ (+) MYH2, MYL1, KLHL40, TNNC2, TNNI2, MYLPF, RPL3L, ATP2A1, FHL3, MYBPC2 (Tabula Sapiens)

⑥ class 5. slow muscle cell

○ (+) MYL1, RP11-451G4.2, RPL3L, MYL6B, MYL2, ANKRD2, MYOZ1, TNNC2, CKM, NRAP (Tabula Sapiens

⑦ class 6. smooth muscle cell

○ (+) AKR1C1, AVPR1A, CCL8, CRISPLD2, CTH, FOXC2, FSTL3, LARS, MYH11, PDGFRB, PDK4, SSTR2, THAP2, TAGLN, Myh11, Pde8b

○ (+) OR51E2, AC131025.8, ADORA2B, MYH11, SLC38A11, MIR143HG, MIR145, RP11-1101K5.1, P2RX3, GPR176, ANO1, OR51E1, CORIN, CACNA1C-IT3, TMC4 (sc-type)

○ (+) MYH10, ITGA8, NOV, SUSD5, SORBS1, MYH11, BGN, CNN1, SMTN, LTBP1 (Tabula Sapiens)

○ (+) ACTA2, CNN1, NOTCH3, MYH11, ACTG2, SOD3, LMOD1, MSRB3, BGN, MYL9, MYLK, SNCG, PLN (PanglaoDB)

○ 6-1. airway smooth muscle cell

○ 6-2. myoepithelial cell

○ (+) CNN1, MYH11, ACTG2, MYLK, MYL9 (PanglaoDB)

○ 6-3. myofibroblast

○ 6-4. pulmonary vascular smooth muscle cell

○ 6-5. vascular smooth muscle cell

○ (+) S100A6, ADIRF, TAGLN, TPM2, ACTA2, MUSTN1, CRIP1, C5H11orf96, TPM1, DSTN (Tabula Microcebus)

⑧ class 7. tendon cell

○ (+) FMOD, THBS4, TNMD, MYOC, XG, ITGA10, FIBIN, CDO1, GEM, CILP (Tabula Sapiens)

⑨ class 8. tongue muscle cell

○ (+) PHACTR3, PAX7, TLN2, CHRNA1, KLHL41, MAP1A, MUSK, H19, HTRA3, NPTX2 (Tabula Sapiens)

⑩ class 9. vascular associated smooth muscle cell

○ (+) RERGL, FHL5, ACTA2, CNN1, MRGPRF, MYLK, ACTG2, TBX2, AOC3, PTP4A3 (Tabula Sapiens)

⑪ class 10. megakaryocyte

○ (+) PF4, ITGA2B, LIPH, ELOVL7, GP6, ITGB3, PTGS1, RP11-480G7.1, RP11-170N16.2, C3orf55, RP4-655J12.4, TUBB1, DCLRE1A, TMEM40, GNAZ (sc-type)

⑫ class 11. Schwann cell

○ (+) UGT8, POU3F1, PMP2, GFRA3, KCNC2, MPZ, SOX10, PTPRZ1, COL20A1, LINC01037, BCAN, C2orf72, C10orf82, RP11-946L20.2, MAG (sc-type)

⑬ class 12. stromal cell

○ (+) WSCD2, C13orf45, LINC00645, RP1-300G12.2, RP11-217C7.1, RP11-332E3.2, RP11-473E2.4, CTD-2555C10.3, RP11-342A23.1, WNT10B, ACKR4, DIO3, CCDC129, ZCCHC5, RP11-38H17.1 (sc-type)

⑭ class 13. satellite cell

○ (+) AC004014.3, MYEOV, TACR3, GDPD4, USP44, RGR, RP11-320P7.2, FAM132B, GPR123, CTB-175P5.4, ENPP7P10, CHRDL2, PAX7, RP11-706J10.1, MAPK15 (sc-type)

⑮ class 14. myometrial cell

○ (+) C16orf45, ACTG2, FHL5, KCNMB1, DES, CNN1, RRAD, HILPDA, LMCD1, PPP1R14A (Tabula Sapiens)

⑷ tissue 3. stem cell

① (+) DMRTA2, FGFR3, RASSF6, COL17A1, PAX6, CHL1, TNS4, KRT12, COL7A1, SYT8 (Tabula Sapiens)

② class 1. brain neural stem cell

○ (+) SOX2, PROM1, NES, SOX9 (sc-type)

③ class 2. cancer stem cell

○ 2-1. kidney cancer stem cell

○ (+) EPCAM

○ 2-2. pancreas cancer stem cell

○ (+) CD24, CD44, FLOT2

○ 2-3. liver cancer stem cell

○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1

○ 2-4. lung cancer stem cell

○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1

○ 2-5. brain cancer stem cell

○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1

④ class 3. immune system stem cell

○ 3-1. pancreas immune system stem cell

○ (+) MS4A1, CD19, CD4, CD8A, CD7, CTLA4, CD27, CCR7, CYTIP, IGHD, CD38, IL2RA, ISG20, SELL, IL7R, FOXP3, IGKC, IGLC3, IGLC2, CD79A, CD68, CD163, CD14, ITGAM, MRC1, MS4A7, CD3D, CD3E, CD3G (sc-type)

○ 3-2. liver immune stem cell

○ (+) CD19, MS4A1, IL2RA, PTPRC, CD4, CD8A, CD3D, CD3E, CD3G, CD11c, CD14, CD16, CD56, CD16, CD42b, CD7, CD8, IgD, CD38, CD24, CD20, CD14, CD16, HLA-DR, CD11b, CD11c, CD123, CD15, CD33, CD66b, CD27, CD94, CD45 (sc-type)

○ 3-3. brain immune stem cell

○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)

○ 3-4. lung immune stem cell

○ (+) ADGRE1, ARG1, BIRC5, CCL17, CCL18, CD14, CD163, CD19, CD22, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD68, CD74, CD80, CD83, CD86, CD8A, CD8B, CDCA3, CDK1, CEBPE, CR2, CSF1R, EAF2, FCER2, FCGR3A, FLT3, GIMAP3P, HLA-DRA, HMMR, IGHM, IL2RA, ITGAE, ITGAM, ITGAX, LAX1, MS4A14, MZB1, NRP1, NUSAP1, PAX5, PRG2, PTPRC, SLPI, THBD, TNFRSF17, TRBC1, XCR1 (sc-type)

⑤ class 4. mesenchymal stem cell

○ 4-1. liver mesenchymal stem cell

○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)

⑥ class 5. skeletal muscle satellite stem cell

⑦ class 6. limbal stem cell

⑧ class 7. epidermal stem cell

○ (+) ITGA6, ITGB1

⑸ tissue 4. bone stroma

① class 1. osteoblast

○ (+) BGLAP, COL1A1, IBSP, Bglap, Alpl

② class 2. osteoclast

○ (+) TRAP, calcitonin receptor (CTR), cathepsin K, NFATC1, SMAD2/3, RXR

③ class 3. osteocyte

④ class 4. osteoclast precursor cell

⑹ tissue 5. hepatic stroma (liver stroma)

① class 1. hematopoietic cell

○ (+) CD34, PTPRC

② class 2. hepatic stellate cell (HSC): These cells play vital roles in liver fibrogenesis. They interact with endothelial cells and hepatic epithelial cells.

○ (+) Desmin, Cd48, Ddx4, Flt3, Kit, Mecom, Procr, Runx1, Slamf1

○ (+) CYGB, PPARG, PDGFRA, RGS5, PPARA, FOXF1, ALB, NR1H4, CCN2, SEMA7A, WT1, FGF10, GFAP, NGFR, VEGFA, ACTA2, MYB, DES, FAP, SLC8A1, RELN, SYP, VCL, TIMP1, COL1A1, TAGLN, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CCN1, OLFML3, IGFBP6, CCL2, COLEC11, HGF (sc-type)

○ (+) PPARG, ALB, CTGF, ACTA2, VCL, TIMP1, COL1A1, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CYR61, OLFML3, IGFBP6, CCL2, COLEC11 (PanglaoDB)

③ class 3. hepatoblast

○ (+) AFP, ALB, CEBPA, KRT14, DLK1, CDH1, FOXM1, GGT1, HNF4A, PROX1, MAP2K4, SMAD5, KRT18, KRT8, HNF1B, HHEX, MET (sc-type)

④ class 4. hepatocyte: Accounts for 60-80% of liver composition.

○ (+) ALB, Apoc4, Uox, Tat, Slc25a47, Cxadr, Gpd1, Hc, Proz, Pzp, Sardh

○ (+) AFP, HNF4A, KRT8, ALB, KRT18, FOSL1, EPPK1, UCP2, GCK, LRP5, SLC10A1, NOS2, ATP7B, GJB2, FGFR4, PROX1, CRP, SLC2A2, TFR2, KIF13B, LIPC, VDR, ASGR1, ARG1, G6PC, OTC, SERPINA1, ZHX2, HHEX, FOXA3, FOXA2, FOXA1, CYP2E1, CYP1A2, CEBPA, CDH1, GPC3, AHR, CPS1, GLS2, PCK1, TAT, WT1, PRRG4, SULT1A1, APOH, CTNNB1, ABCC3, FGB, AQP3, PLSCR1, FGA, APOB, ANG, ANXA13, SAT2, SFRP5, A1CF, APOA1, BNIP3, FGL1, PAH, SERPINA6, APOA2, AZGP1, FGG, APOC3, DEFB1, TM4SF4, GC, AMBP, ORM1, TTR, HAL, ASS1, SCD, HMGCS1, ACSS2, TM7SF2, SEC16B, SLBP, RND3, BCHE, GHR, ALDH6A1, MASP2, AKR1C1, HAMP, GLUL, ACLY, ASL, TMEM97, CP, SLPI, ACAT2, TM4SF5, MSMO1, LEPR, RCAN1, AR, RPP25L, HSD11B1, APOM, TKFC, G0S2, PON3, C1orf53, TTC36, FST, MCC, AQP9, GSTA2, NNT, SAA4, MRPS18C, OCIAD1, APOA5, ENTPD5, C4B, EID2, TP53INP2, ATIC, SERPINH1, SAMD5, GRB14, CD3G, RHOB, EPB41L4B, GPAT4, SPTBN1, SDC2, PHLDA1, WTAP, ACADM (sc-type)

○ (+) MAT1A, AGXT, KNG1, TAT, CRP, ITIH1, HPX, APOA2, CYP2E1, CPS1 (Tabula Sapiens)

○ (+) ALB, SERPINA1, APOH, FGB, FGA, APOA1, FGL1, APOA2, FGG, APOC3, AMBP, ORM1, TTR (PanglaoDB)

○ 4-1. periportal hepatoycyte

○ (+) SDS (gulconeogenesis), Alb, Cyp2f2, Sds (gulconeogenesis)

○ 4-2. pericentral hepatocyte (centrilobular hepatocyte)

○ (+) GLUL, CYP2E1, Cyp2e1, Gsta3

○ note. pericentral → periportal gradient (ref)

○ Glul, Oat, Cyp2a5, Mup9, Mup17, Cyp2c29, Cyp2e1, Mup11, Hamp, Ass1, Serpina1e, Cyp2f2, Alb, Mup20

⑺ tissue 6. eye stroma

① class 1. bipolar cell

○ (+) NRSN1, SLC24A2, VSX2, CELF3, STMN4, MDGA2, TMEM179, TMEM196, GNG13, GNG3 (Tabula Sapiens)

○ 1-1. rod bipolar cell

○ (+) PRKCA, PCP4, RCVRN, SLC1A2, Car8, Sebox, Vsx2, Otx2, GRM3, KCNA4, KCNMA1, RORB, Cabp5, Og9x, Vstm2b, Casp7, Rpa1, GABRA1, LHX4 (sc-type)

○ 1-2. cone bipolar cell

○ (+) PCP4, RCVRN, SLC1A2, Car8, Scgn, Vsx2, Otx2, MIP, GNAS, ISL1, SLC1A7, GJD2, GNB3, GRIA4, TJP2, LRIT2, Cabp5, Scgn, Vsx1, GABRA1, LHX4, LHX3 (sc-type)

② class 2. muller cell

○ (+) Apoe, Glul, Rlbp1, Abca8a, Vim, Aldh1a1, RLBP1, GLUL, PAX6, CA8, EDN2, KCNJ2, PRSS56, RGR, ApoE, Aqp4 (sc-type)

○ (+) RLBP1, RAX, FABP7, GFAP, CRABP1, MT-TV, LINC00461, DEFB119, RGR, LINC00632 (Tabula Sapiens)

③ class 3. astrocyte

○ (+) PRDX6, SLC1a3, PAX2, Rlbp1, GFAP, S100B (sc-type)

④ class 4. retinal ganglion cell

○ (+) BMP4, GRIA4, GRM3, KCNJ2, MED1, NMT, POU6F2, ZIC2, SLC17a6, Pax6, THY1, Nefl, Pou4f2, SNCG, NRN1, Cerkl (sc-type)

○ (+) NHLH2, SMIM18, CCDC184, NKAIN3, SRRM3, NARF, CPNE4, CACNB3, SLC17A6, DNER, FXYD7, NEFM, SNCG (PanglaoDB)

⑤ class 5. retinal progenitor cell

○ (+) PAX6, CALB2, SIX6, RHO, SIX3, NEFH, LGR5, SAG, RAX, NOTCH1, HES1, MSI1, SOX9, KIT, PDGFRA, Og9x, Sfrp2, Fgf15 (sc-type)

⑥ class 6. GABAergic amacrine cell

○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln (sc-type)

⑦ class 7. horizontal cell

○ (+) Rcvrn, Prox1, Ntrk1, Lhx1, Lim2, Calb2, CALB1, LIM1, DLG2, TFAP2B, ZEB2, Lim1 (sc-type)

⑧ class 8. synapse

○ (+) SYP, DLG4, HOMER1, SLC32A1 (sc-type)

⑨ class 9. fibroblast

○ (+) PAX6, COL1A1, TGFB1, ACTA2, ICAM1, FBLN1, CRHBP, FN1, PDGFRA (sc-type)

⑩ class 10. pericyte

○ (+) Kcnj8, Rgs5, Dlk1, Abcc9, SUR2B, DLK1, VCAM1 (sc-type)

⑪ class 11. extracellular matrix cell

○ (+) ANTXR2, COL10A1, EFEMP1, LAMA2, SNTB1, TCF7L2, TGFBR1, TMEM98, VIPR2, ZIC2 (sc-type)

⑫ class 12. glycinergic amacrine cell

○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Slc6a9, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GlyT1, TgfB2, BE996002, Camkv, TCF4, Efna5, Dab1, Slc6a9 (sc-type)

⑬ class 13. Cholinergic GABAergic amacrine cell

○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln, VAChT, Tac1, Scube2, Cpne4, Sox2, Slit, SCGN (sc-type)

⑭ class 14. Tachykinin GABAergic amacrine cell

○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln, ZPF58, Cdh4, Grik4, Grm8, Slit2, SCGN (sc-type)

⑮ class 15. Starburst amacrine cell

○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GAD1, CHAT, SLC5A7 (sc-type)

⑯ class 16. adipocyte

⑰ class 17. ciliary body

⑱ class 18. beam cell (A/B/X/Y): fibroblast-like (ref)

⑲ class 19. JCT(juxtacanalicular tissue) cell

⑳ class 20. retina neuron layer

○ L1

○ L2

○ L3

○ L4

○ L5

○ L6

○ L7

○ L8

○ L9

○ L10

⑻ tissue 7. pancreatic stroma

① class 1. pancreatic acinar cell

○ (+) CTRB1, KLK1, RBPJL, PTF1A, CELA3A, PRSS1, SPINK1, ZG16, CEL, CELA2A, CPB1, CELA1, RNASE1, AMY2B, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, CFB, GDF15, MUC1, C15orf48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, LYZ, ANGPTL4, ALDOB (sc-type)

○ (+) AMY2A, CELA3B, CELA3A, CELA2A, CTRB2, CPA2, PRSS3P2, PNLIPRP1, CTRL, PNLIPRP2 (Tabula Sapiens)

○ (+) PRSS2, CPA1, CTRC, LOC105875474, LOC105873340, CTRB1, LOC105873633, CLPS, PLA2G1B, LOC105873613 (Tabula Microcebus)

○ (+) CTRB1, KLK1, CELA3A, PRSS1, SPINK1, CPB1, RNASE1, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, GDF15, MUC1, C15ORF48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, ALDOB (PanglaoDB)

② class 2. pancreatic alpha cell

○ (+) GCG, TTR, ARX, POU3F4, NKX2-2, RESP18, PYY, PCSK2, SLC38A5, TM4SF4, CRYBA2, NKX6-1, KCNK16, PCSK1, PRRG2, IRX2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SH3GL2, SCGB2A1, FAP, DPP4, MAFB, PAX6, NEUROD1, PLCE1, GC, KLHL41, FEV, PTGER3, RFX6, SMARCA1, PGR, LDB2, IRX1, UCP2 (sc-type)

○ (+) GCG, TTR, PCSK2, TM4SF4, CRYBA2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SCGB2A1, MAFB, NEUROD1, GC, FXYD5 (PanglaoDB)

③ class 3. pancreatic beta cell

○ (+) FXYD2, PDX1, INS, GCGR, JPH3, CD40, HAMP, EZH1, NTRK1, SLC2A2, NKX6-2, NPY, RIMS1, MAFA, EFNA5, LMX1A, NKX2-2, NKX6-1, PAX4, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, IGF2, SYT13, FFAR2, NPTX2, PFKFB2, EDARADD, HOPX, SH3GL2, ADCYAP1, SCGB2A1, CASR, MAFB, PAX6, NEUROD1, ISL1, TGFBR3, SMAD9, SIX3, SIX2, BMP5, PIR (sc-type)

○ (+) PDX1, INS, MAFA, NKX2-2, NKX6-1, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, SYT13, NPTX2, HOPX, ADCYAP1, SCGB2A1, MAFB, PAX6, NEUROD1, ISL1, DLK1, MEG3 (PanglaoDB)

④ class 4. pancreatic delta cell

○ (+) SST, PDX1, FFAR4, PCSK9, RBP4, PAX4, RESP18, HHEX, ISL1, SCGN, KCNK16, IAPP, FXYD2, NPTX2, GPC5-AS1, UCP2, LEPR, BAIAP3, MS4A8, CASR, BCHE, GABRB3, UNC5B, EDN3, PRG4, FRZB, PCSK1, GABRG2, POU3F1, BHLHE41, EHF, LCORL, ETV1 (sc-type)

○ (+) SST, RBP4, HHEX, ISL1, SCGN, IAPP, GPC5-AS1, PCSK1 (PanglaoDB)

⑤ class 5. pancreatic epsilon cell

○ (+) GHRL, ANXA13, PHGR1, BMP4, HMGCS2, TM4SF5, OLFML3, ASGR1, COX6A2, NPY1R, SLC7A9, BHMT, OPRK1, PTGER4, ITGA4, EYA4, XYLB, ELOVL2, AFF3, CORIN, MYO1A, HRH2, SLC6A16, PCSK6, ADAMTS6, COL22A1, FAM124A, COL12A1, CD109, THSD4, ARX (sc-type)

⑥ class 6. pancreatic gamma (PP) cell

○ (+) PPY, SCGN, FXYD2, SCGB2A1, GPC5-AS1, CMTM8, ARX, ETV1, PXK, SERTM1, SLITRK6, SEMA3E, APOBEC2, ABCC9, NEUROD1, PAX6, ISL1, CARTPT, THSD7A, AQP3, ENTPD2, PTGFR, CHN2, EGR3, LMO3, MEIS1, ZNF503 (sc-type)

○ (+) PPY, SCGN, SCGB2A1, GPC5-AS1, CMTM8, NEUROD1, AQP3 (PanglaoDB)

⑦ class 7. langerhans cell

○ (+) CD1A, Langerin (CD207), EpCAM, CD11c, RUNX3, ID2, AHR

○ (+) CD207, CCL22, DAPP1, C15orf48, TRAF1, NEDD4, HLA-DQA2, GNA15, GPR157, HLA-DQB2 (Tabula Sapiens)

○ (+) HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 (PanglaoDB)

⑧ class 8. pancreatic A cell

○ (+) GCG, KCNK16, CRH, SLC30A8, CPLX2, NKX2-2, CRYBA2, CHGA, INSM1, RFX6 (Tabula Sapiens)

⑨ class 9. pancreatic D cell

○ (+) KCNK16, GCG, SST, CRH, AVPR1B, GAD2, GPC5-AS1, ACTL6B, CPLX2, RP5-984P4.6 (Tabula Sapiens)

⑩ class 10. pancreatic PP cell

○ (+) PPY, GPC5-AS1, GAD2, PAM, NKX2-2, CALB1, SLC30A8, ARX, SCG2, STMN2 (Tabula Sapiens)

⑪ class 11. TypeB pancreatic cell

○ (+) KCNK16, GAD2, G6PC2, IAPP, FAM159B, RP5-984P4.6, MIR7-3HG, NKX2-2, SLC30A8, CELF3 (Tabula Sapiens)

⑼ tissue 8. intestine stroma

① (+) TRAC, TRBC1

② class 1. enterocyte

○ (+) KRT20, PPARG, FABP1, ANPEP, CA1, FABP2, VIL1, CDH17, CDC42EP5, HNF4A, TMEM45B, ELF3, TMC4, PPP1R14D, CEACAM1, KLF5, CDX1, CDX2, PRR15L, MUC13, PHGR1, LGALS2, CD55, SLC26A2, SLC26A3, SLC51B, ABCG2, ACSL5, AQP8, SLC39A5, MAOA, DGAT1 (PanglaoDB)

○ 1-1. immature enterocyte

○ 1-2. mature enterocyte

○ (+) UGT2B17, LGALS4, FABP2, CHP2, CDX2, PPP1R14D, FABP1, CDH17, TSPAN8, CES2 (Tabula Sapiens)

○ 1-3. proximal enterocyte

③ class 2. crypt cell

○ 2-1. intestinal crypt stem cell

○ (+) TSPAN8, UGT2B17, SLC12A2, URAD, LEFTY1, ADH1C, RGMB, CDX2, LGALS4, CHP2 (Tabula Sapiens)

○ 2-2. intestinal crypt stem cell of large intestine

○ (+) RN7SK, RNU6ATAC, MAFA, HSPA2, HIST4H4, CSRNP2, HIST1H2AG, PARD6G-AS1, DLL4, MTMR11 (Tabula Sapiens)

○ 2-3. intestinal crypt stem cell of small intestine

○ (+) APOBEC1, CCL25, RBP2, CLDN15, MISP, SLC39A4, PRAP1, ARL14, RHPN2, AC021218.2 (Tabula Sapiens)

④ class 3. goblet cell

○ (+) Ido1

○ (+) MUC2, ITLN1, TFF3, AGR2, PHGR1, MUC13, FCGBP, ZG16, KLK1, SPINK4 (PanglaoDB)

○ 3-1. large intestine goblet cell

○ (+) MUC2, BEST2, CLCA1, ZG16, TFF3, ST6GALNAC1, REP15, FCGBP, HEPACAM2, WNK4 (Tabula Sapiens)

○ 3-2. small intestine goblet cell

○ (+) CLCA1, MUC2, ZG16, SPINK4, FER1L6, TFF3, ITLN1, SCNN1A, REG4, GALNT8 (Tabula Sapiens)

⑤ class 4. transit amplifying cell

○ 4-1. transit amplifying cell of large intestine

○ 4-2. transit amplifying cell of small intestine

○ (+) CCL25, RBP2, FABP2, MUC17, SLC5A1, CLDN15, PRAP1, OLFM4, CHP2, VIL1 (Tabula Sapiens)

○ 4-3. transit amplifying cell of colon

○ (+) NOX1, URAD, LEFTY1, UGT2B17, LGALS4, CDX1, CDX2, NXPE4, TSPAN8, PPP1R14D (Tabula Sapiens)

⑥ class 5. intestinal enteroendocrine cell

○ (+) NKX2-2, INSM1, MIR7-3HG, FEV, CHGA, RFX6, CRYBA2, RIMBP2, PCSK1N, SCG3 (Tabula Sapiens)

○ (+) SCGN, SST, GCG, CHGB, CPE, IAPP, CHGA (PanglaoDB)

⑦ class 6. intestinal tuft cell

○ (+) TRPM5, IL17RB, PLCG2, SH2D6, LY6H

○ (+) GNAT3, SH2D7, GNG13, CCDC129, TRPM5, LRMP, SH2D6, MATK, CCSER1, POU2F3 (Tabula Sapiens)

⑧ class 7. enteric glia cell

○ (+) GFRA3, MPZ, LGI4, RGS16, ALDH1A1, L1CAM, DKK3, INTS6, DHRS3, S100B (PanglaoDB)

⑨ class 8. enteric neuron

⑩ class 9. enterochromaffin cell

⑪ class 10. foveolar cell

⑫ class 11. gastric chief cell

⑬ class 12. microfold cell

⑭ class 13. paneth cell

⑮ class 14. parietal cell

⑯ class 15. telocyte

⑽ tissue 9. kidney stroma

① class 1. podocyte

○ (+) NPHS1, NPHS2, EZR, TDRD5, SEMA3G, SEMA5A, SEMA3E, PLA2R1, COL4A4, ARHGAP24, WT1, COL4A3, RHPN1, MAFB, PODXL, CLIC5, CD2AP, NOTCH2 (sc-type)

○ (+) PODXL, VEGFA, SYNPO, NPHS1, NPHS2, WT1, PTPRO, THSD7A, MAFB, ENPEP, CLIC5, BCAM, MAGI2, EFNB1, PLOD2, SRGAP1, TCF21, PTH1R, CTGF, TRIB2, DACH1, AIF1L, GOLIM4, TOB1 (PanglaoDB)

② class 2. cancer stem cell

○ (+) EPCAM

③ class 3. mesangial cell

○ (+) PDGFRB, PDGFB, LAMA4, ITGA8, LGALS1, ARID5B, CCR7, FN1, GATA3, PAWR, SERPINE2, TBX18, TEK, THY1, REN, ZEB2 (sc-type)

○ (+) PDGFRB, ANGPT2, CTGF, GATA3, ITGA8, ARID5B, FN1, PTN, MYL9, TPM2, CALD1, HOPX, ACTN1, AKAP12, ROCK1, SH3BGRL, FILIP1L, FLNA, MEF2C, CSTB, MAP3K20 (PanglaoDB)

④ class 4. cap mesenchyme cell (mesenchymal cell)

○ (+) SIX2, ITGA8, NR2F2, EYA1, MEIS2, CITED1, MUC1, NOTCH2 (sc-type)

⑤ class 5. stromal cell

○ (+) MEIS1, TCF21, COL1A2, COL3A1, TNC, COL6A3, LGALS1 (sc-type)

⑥ class 6. juxtaglomerular cell

○ (+) REN, CRIP1 (sc-type)

⑦ class 7. renal interstitium (mesenchymal cell)

○ (+) SFRP1, MEIS1, PDGFRA, C7, MGP (sc-type)

⑧ class 8. cancer stem cell

○ (+) EPCAM (sc-type)

⑨ class 9. kidney progenitor cell

○ (+) PAX2, EYA1, WT1, CITED1 (PanglaoDB)

⑩ class 10. principal cell

⑪ class 11. proximal tubule cell

⑫ class 12. transient cell

⑾ tissue 10. brain stroma

① class 1. neuron

○ (+) ENO2, NEFM, SLC12A5, TMEM130, CLSTN3, ARID4A, RHBDD2, TMEM59L, MIAT, AAK1, SPOCK3, DNM3, DNER, CHN1, GABBR2, MEG3, BEX2, BEX1, CAMK2N1, PNISR, STMN2, SNAP25, VSNL1, ATP6V0A1, MYO5A, DYNC1I1, ELAVL3 (PanglaoDB)

○ (+) CAMKV, EPHA3, NEUROD6, SLC24A2, NELL1, GAP43, SOX11, ELAVL4, BEX1, RTN1, SNAP25, SYT1, ELAVL3, STMN2, STMN4 (SCEVAN)

○ 1-1. cholinergic neuron

○ (+) Slc18a3

○ (+) CHAT, SLC18A3, ACHE (sc-type)

○ 1-2. dopaminergic neuron

○ (+) Slc6a3

○ (+) TH, SLC6A3, FOXA2, KCNJ6, NR4A2, LMX1B, DBH, SLC6A2, PPP1R1B (sc-type)

○ 1-3. GABAergic neuron

○ (+) Slc32a1

○ (+) SLC6A1, GABBR1, GABBR2, GAD2, GAD1, SLC32A1 (sc-type)

○ 1-4. glutamatergic neuron

○ (+) Slc17a7, Slc17a6, Slc17a8

○ (+) SLC17A7, SLC17A6, GRIN1, GRIN2B, GLS, GLUL, GRIN2A (sc-type)

○ 1-5. serotonergic neuron

○ (+) Slc6a4

○ (+) TPH1, SLC6A4, FEV, HTR1A, HTR1B (sc-type)

○ (+) TPH1, FEV, DDC (PanglaoDB)

○ 1-6. adrenergic neuron

○ 1-7. glycinergic neuron

○ (+) Slc6a5

○ 1-8. noradrenergic neuron

○ (+) Slc6a2

○ 1-9. histaminergic neuron

○ (+) Hdc

○ 1-10. bipolar neuron

○ 1-11. immature neuron

○ (+) DCX, NEUROD1, TBR1, STMN1, NCAM1, TUBB3 (sc-type)

○ 1-12. mature neuron

○ (+) RBFOX3, MAP2, SYP, DLG4, TUBB3, MAPT, INA, GAP43, NRP1 (sc-type)

○ (+) TUJ1

○ 1-13. neural progenitor cell

○ (+) CSPG4, RNF5, EOMES, SOX2, SOX1, NES, PAX3, PAX6, OTX2, CNTNAP1, ASCL1, SMARCA4, MSI1, MSI2 (sc-type)

○ 1-14. neural stem cell

○ (+) SOX2, PROM1, NES, SOX9 (sc-type)

○ 1-15. interneuron

○ 1-15-1. interneuron progenitor

○ (+) Dlx1, Dlx2, Lhx6, Nkx2-1

○ 1-16. peripheral nerve

○ (+) MPZ, S100B, LGI4, PLP1

○ 1-17. motor neuron

○ 1-18. noradrenergic neuron

○ 1-19. Purkinje neuron

○ (+) Pcp4, Car8, Calb1, Slc1a3, Ppp1r17, Pvalb

○ 1-20. pyramidal cell

○ 1-21. trigerminal neuron

○ 1-22. granule neuron

○ (+) Snap25, Cbln3, Gabra6

○ 1-23. MSN(medium spiny neuron)

○ (+) Gpr88

○ 1-24. olfactory bulb

○ region 1. glomerular layer

○ (+) Eomes

○ region 2. mitral layer

○ (+) Eomes

○ state 1. inhibitory neuron

○ (+) Lamp5, Sncg, Vip, Sst, Pvalb

② class 2. glial cell

○ 2-1. glioblasts

○ (+) Aldh1l1, Efna5, Wnt1, Wnt9a, Rspo1/2/3

○ 2-2. neuroblasts

○ (+) Npas3, Adgrb3, Fgf15, Wnt7b, Tnc

○ (+) NEUROD1, DCX, DLX2, PROX1, EOMES, TUBB3 (sc-type)

○ 2-3. radial glial cell

○ (+) Mki67, Dbx1, PAX6, HES1, HOPX

○ (+) VIM, NES, PAX6, HES1, HES5, GFAP, SLC1A3, FABP7, TNC, CDH2, SOX2 (sc-type)

○ (+) SOX15, RP11-54H7.4, FAM83A, LAMC2, BNC1, IRF6, ITGA2, DMRTA2, COL17A1, LAMA3 (Tabula Sapiens)

○ 2-4. Schwann cell

○ (+) UNC93B6, FOXD3, AC012470.1, DLX1, FOXD3-AS1, RP5-907C10.3, GDNF-AS1, SMIM41, PLP1, KLHDC8A

○ 2-4-1. myelinating Schwann cell

○ (+) SOX10, EGR2, MBP, MPZ (sc-type)

○ 2-4-2. non myelinating Schwann cell

○ (+) SOX10, GAP43, NCAM1, NGFR (sc-type)

○ 2-4-3. Schwann precursor cell

○ (+) SOX10, GAP43, FABP7, MPZ, DHH, NGFR (sc-type)

○ 2-5. astrocyte

○ (+) Gfap, S100b

○ (+) GFAP, SLC1A3, SLC1A2, GLUL, S100B, ALDH1L1, AQP4, IGFBP3, ATP13A4, CBS, SOX9, CD40, CD80, CD86, C5AR1 (sc-type)

○ (+) S100B, SLC1A2, GFAP, SLC1A3, FGFR3, AQP4, AGT, GPR37L1, SLC6A11, SYNE1, PLXNB1, GJA1, APOE (PanglaoDB)

○ 2-6. oligodendrocyte

○ (+) Mbp, Plp1, Mobp, Car2

○ (+) OLIG1, OLIG2, OLIG3, CLDN11, MBP, MOG, MAG, GALC, CNP, SOX10, FA2H, UGT8 (sc-type)

○ (+) MOG, TF, TMEM63A, PTGDS, MYRF, SEMA4D, GJB1, ERMN, CLDN11, ANLN, PLLP, PEX5L, ST18, MAG, ENPP2, PLP1, MBP (PanglaoDB)

○ (+) OLIG2, NKX2-2, SOX10, AACS, AARD, ABCA6, ABCA8, ABCB4, ABHD4, ABLIM2, ABTB2, AC023908.1, AC136616.1, ACAN, ACAP3 (SCEVAN)

○ 2-6-1. oligodendrocyte precursor cell (OPC, NG2)

○ (+) Ptprz1

○ (+) LHFPL3, MEGF11, PCDH15, PDGFRA, CSPG4, RNF5 (sc-type)

○ (+) PDGFRA, GPR37L1, VCAN, EPN2, OLIG1, TNR, CNP (PanglaoDB)

○ 2-6-2. myelinating oligodendrocyte

○ (+) GALC, GPR17, MYRF, CNP, HES5, IL1RAP, NKX2-2, MBP, CLDN11, PLP1UGT8, MOG, SOX10, ERMN, MAG, MOBP (SCEVAN)

○ (-) Ptprz1

○ 2-7. tanycyte

○ (+) GPR50, COL23A1 (sc-type)

○ 2-8. Bergmann glia

○ (+) Gfap

○ 2-9. Cajal-Retzius cells

○ 2-10. ganglion cell

○ 2-11. pinealocyte

○ 2-12. satellite glial cell

③ class 3. neuroendocrine cell

○ (+) Kcna1, Olfr558, Mpz, Casq2, Rgs5, Plp1, Pln, Sox10, Nrip2, Rgs4 (Tabula Muris)

⑿ tissue 11. lung stroma

① class 1. ciliated cell

○ (+) Dynlrb2, Foxj1

○ (+) APPL2, ATP5MD, CCDC153, CCDC17, CCDC181, CCDC39, CYP2S1, FAM161A, FOXJ1, LRRC23, ODF3B, SCGB1A1, SEC14L3, SNTN, STK11, TMEM212, TSPAN19, TUBB4B (sc-type)

○ (+) RP11-680N20.1, APOBEC4, RP11-60L3.6, RP11-122M14.1, EPPIN, DNAI1, AC009502.4, AC005281.1, LDLRAD1, SNTN (Tabula Sapiens)

○ (+) C20orf85, SNTN, ANKRD66, C11orf88, TMEM190, FAM216B, SRGAP3-AS2, STOML3, PIH1D3, C1orf194 (Tabula Sapiens)

○ 1-1. airway ciliated cell

② class 2. airway goblet cell

○ (+) AGR2, AQP5, CEACAM1, DMBT1, DUSP4, FXYD3, GALNT5, GALNT6, GGH, GOLPH3, GP2, IL19, LIPF, LTF, LYNX1, MSLN, MUC16, MUC4, MUC5B, NOS2, PIGR, QSOX1, SCGB3A1, SEC23B, SPDEF, TFF2 (sc-type)

③ class 3. hair follicle cells

○ (+) Krt5, Krt17

④ class 4. ionocyte (chloride cell): mitochondrion-rich cell

○ (+) GPRC6A, ASCL3, FOXI1, BSND, FOXI2, LCNKB, TMPRSS11E, ATP6V0A4, TMEM61, ATP6V1C2 (Tabula Sapiens)

⑤ class 5. neuron

⑥ class 6. pulmonary ionocyte

○ (+) DMRT2

○ (+) CFTR, CLCNKB, FOXI1, KCNMA1, SCGB1A1, SLC12A2, TFCP2L1 (sc-type)

○ (+) CLDN25, ATP6V1G3, LINC00706, ASCL3, LINC01187, DDX4, CYP26A1, STAP1, SP9, BSND (Tabula Sapiens)

⑦ class 7. respiratory goblet cell

○ (+) SCGB1A1, BPIFB1, SCGB3A1, CYP2F1, VMO1, MUC5B, CXCL6, MSMB, CCNO, CYP2J2 (Tabula Sapiens)

⑧ class 8. respiratory mucous cell

⑨ class 9. pericyte

⑩ class 10. fibroblast

○ COL3A1, COL5A2, DPT, FN1, GSN, LRP1, PDGFRA, TCF21 (sc-type)

○ 10-1. adventitial fibroblast: specialized pericytes

○ 10-2. alveolar fibroblast

○ 10-3. intermediate pathological fibroblast

○ 10-4. mesothelial fibroblast

○ 10-5. pathological fibroblast

⑪ class 11. basal cell (airway progenitor cell)

○ ABI3BP, AQP3, DAPL1, GSTM2, HPGD, ICAM1, KRT14, KRT15, KRT5, PHLDA3, RPS18, SDC1 (sc-type)

○ 11-1. airway basal cell

⑫ class 12. clara cell

○ AHR, ALDH1A1, BPIFA1, CTSE, CYP2E1, CYP4B1, ERN1, FOXM1, LEPR, MUC1, MUC4, MUC5B, RAB3D, SCGB1A1, SCGB3A1, SCGB3A2, SFTPA1, SFTPC, SFTPD, SYT2 (sc-type)

○ SCGB1A1, SCGB3A2, SFTPC, MUC1, CYP4B1, SCGB3A1, SFTPA1 (PanglaoDB)

⑬ class 13. secretory cell

○ MUC5B, PIGR, SCGB1A1 (sc-type)

⑭ class 14. airway mucous cell

⑮ class 15. smooth muscle

○ 15-1. airway smooth muscle

○ 15-2. vascular smooth muscle

⑯ class 16. cancer stem cell

○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1 (sc-type)

⑰ class 17. adventitial cell: specialized pericyte

○ (+) TSKU, GFPT2, MFAP4, PCOLCE, SPOCK1, GPR133, PI16, GFRA1, FIBIN, PDGFRL (Tabula Sapiens)

⒀ tissue 12. adrenal stroma

① class 1. CSH1_CSH2 positive cell

○ (+) CGB, GH2, PSG5, CGA, CSH1, ERVW-1, CSH2, PSG7, PSG11, HSD3B1, PSG9, PSG1, PSG6, PLAC4, PSG4 (sc-type)

② class 2. megakaryocyte

○ (+) C15orf54, GP9, PF4, PPBP, GP1BA, MEGT1, LY6G6F, GP6, ITGA2B, C6orf25, ALOX12, FCER1A, ELOVL7, NRGN, RP11-930O11.1 (sc-type)

③ class 3. Schwann cell

○ (+) WNT16, MPZ, FOXD3, SOX10, CDH19, GPR17, PMP2, COL20A1, INSC, RP4-792G4.2, TTYH1, SOX2, LAMP5, OLFML2A, ATP1A2 (sc-type)

④ class 4. sympathoblast

○ (+) NPAS4, SLC24A2, RP11-542G1.2, PENK, LINC00890, KLK4, RP11-17A4.2, RP5-1096J16.1, C18orf42, TTC40, ARC, FAM19A3, VWA5B1, PPP1R17, RP4-718N17.2 (sc-type)

⑤ class 5. stromal cell

○ (+) MIR1245A, NPY5R, RP11-60A8.1, RP11-254F19.2, RP11-494K3.2, RP11-758M4.4, RP11-142A23.1, RP11-752L20.5, OSR1, RP11-867G23.13, SULT1E1, HHIP, MGP, PRELP, TWIST2 (sc-type)

⑥ class 6. Chromaffin cell

○ (+) NRG1-IT3, RNU6-457P, LINC00594, AC018643.4, RP11-159N11.3, CTC-537E7.1, Y_RNA, snoU13, CTD-2006K23.2, RP5-955M13.4, INSRR, KCNK10, PHEX-AS1, RP11-958J22.1, FLJ30594 (sc-type)

⑦ class 7. adrenocortical cell

○ (+) RP1-145M24.1, RP11-238I10.1, AC005392.13, RP11-316I3.2, RP11-501O2.4, SDIM1, RP11-258O13.1, AJ006998.2, CTD-2517O10.5, RNU6-944P, CTB-43E15.4, RP11-34F13.3, RP11-536K7.5, RP11-183M13.1, RNU6-56P (sc-type)

⑧ class 8. SLC26A4_PAEP positive cell

○ (+) IL1A, SLC26A4, SNX25P1, VMO1, CTD-2210P15.2, CTC-360P9.4, ULK4P1, SNORA14A, RNU6-518P, RP11-431N15.2, RP11-26J3.3, RP11-378A12.1, SPINK8, HSD3B2, KIRREL-IT1 (sc-type)

⒁ tissue 13. heart stroma

① megakaryocyte

○ (+) MEGT1, LY6G6F, TUBB1, PPBP, PF4, GP9, TPSB2, HBD, AC137932.6, ITGA2B, GP1BA, CLEC1B, PTCRA, BEND2, RP11-179A10.1 (sc-type)

② epicardial fat cell

○ (+) RP11-89M22.3, CTD-3012A18.1, PRG4, KRT7, SPRR2F, KLK11, MKRN9P, UPK1B, EPGN, NPHS1, ITLN1, LRRN4, CST6, GSDMA, RAET1E (sc-type)

③ Schwann cell

○ (+) GFRA3, SOX10, MPZ, LINC00466, COL20A1, MIA, ASPA, ERBB3, TFAP2A, INSC, ARTN, PMP2, S100B, FOXD3, AP000797.3 (sc-type)

④ endocardial cell

○ (+) ANGPTL5, APCDD1L, NPPC, SLC6A4, SALL1, LEPR, C3orf36, AC004562.1, FAM3D, HAPLN1, APCDD1, LYPD2, FOXC1, MPZL2, RP11-849I19.1 (sc-type)

⑤ stromal cell

○ (+) RP11-60A8.1, SCARA5, DPT, CILP, ZCCHC5, AGTR2, MFAP5, RP11-71N10.1, LUM, ABCA10, RP11-31K23.2, CCL11, NRK, PDGFRA, LPAR4 (sc-type)

⑥ smooth muscle cell

○ (+) PDE4C, RP11-112H10.4, RP11-598F7.5, RP11-626H12.1, HCG22, CTD-3064M3.3, RP11-231I13.2, GPR20, RP11-267N12.1, OR51E1, THBS4, MIR143HG, PDGFRB, AOC3, ENPEP (sc-type)

⑦ SATB2_LRRC7 positive cell

○ (+) NEUROD2, FEZF2, NEUROD6, TBR1, MPPED1, SATB2, FOXG1, PCDH11Y, CAMKV, BHLHE22, SLIT1, C14orf23, RP11-562L8.1, LINC00966, DRAXIN (sc-type)

⑧ visceral neuron

○ (+) GATA3-AS1, GAL, CHRNA3, PRPH, PHOX2A, GALR1, NXPH1, TMC3, DDC, SST, OPRM1, PIRT, NECAB2, ECEL1, SLC10A4 (sc-type)

⑨ cardiomyocyte

○ (+) Myh6, Myh7, Tnnc1

○ (+) MYH6, TECRL, COL2A1, AC020909.2, NKX2-5, FBN2, TNNT2, MYL4, MYL7, ACTC1 (Tabula Sapiens)

○ (+) RP11-439H8.4, RNA5SP327, CTD-2552K11.2, Y_RNA, AC018464.3, HHATL, BMP10, RP11-461A8.4, UGT2B4, PRSS42, WI2-1896O14.1, FABP2, EPN3, RP11-406O23.2, AC009878.2 (sc-type)

⑩ ELF3_AGBL2 positive cell

○ (+) C1orf194, ZMYND10, MS4A8, IL20RA, ELF3, SCGB3A2, EFCAB1, SFTPB, WDR65, CP, PIH1D2, AGBL2, SFTPC, DNAH9, MUC1 (sc-type)

⑪ CLC_IL5RA positive cell

○ (+) FAM209A, CERKL, CLC, PRG2, MS4A3, IL5RA, ZC2HC1C, CTD-2620I22.1, CTD-3032H12.2, RP11-252E2.1, AC011524.1, S100A1, Y_RNA, LINC00407, RP11-516C1.1 (sc-type)

⑫ cardiac stem and precursor cell

⑬ his bundle cell

⑭ Purkinje fiber cell

⑮ Cajal cell

⒂ tissue 14. intestine stroma

① chromaffin cell

○ (+) ARX, NKX2-2, CCK, CRYBA2, NEUROD1, FEV, MLN, ASIC5, ONECUT3, SST, RP11-788H18.1, PAX4, KCNH6, SSTR5, PCSK1 (sc-type)

② smooth muscle cell

○ (+) ACTG2, GREM2, CNN1, RP11-467I20.6, WIF1, TACR2, OVCH2, FRMD6-AS2, DES, MYH11, RP11-626H12.1, ANO1, CHRDL2, TAGLN, FBXL22 (sc-type)

③ ENS glia

○ (+) SERPINA3, RLBP1, GPR12, RP4-792G4.2, CDH19, COL20A1, SOX10, PLP1, SOX2, FOXD3, MPZ, BCAN, TFAP2A, SOX2-OT, PTPRZ1 (sc-type)

④ ENS neuron

○ (+) PDIA2, RP11-672L10.2, GRP, DRGX, GCGR, SLC18A3, PHOX2A, HECW1-IT1, RP11-202H2.1, IQCJ, STMN4, TTC9B, GAL, CEND1, NEFL (sc-type)

⑤ stromal cell

○ (+) RP11-13P5.2, MSC, RP1-283K11.3, RP5-1077H22.1, CTD-2541J13.1, AC002511.2, AC002511.3, MMP27, CTD-2334D19.1, CXCL14, FZD10, PDGFRA, AC003090.1, RP1-288H2.4, ITGA11 (sc-type)

⒃ tissue 15. placenta stroma

① PAEP_MECOM positive cell

○ (+) RP11-98L5.2, AC104654.1, PAEP, RP11-274B18.4, PIGR, TSPAN1, AC012593.1, RP11-510D19.1, POU5F1, UGT2B7, DEFB1, RP11-697E22.2, SLC18A2, PAX8, SLPI (sc-type)

② AFP_ALB positive cell

○ (+) SLC2A2, ALB, APOB, AFP, ITIH2, F2, MAT1A, APOC3, SERPINC1, FABP1, APOA2, AHSG, SERPINA10, SLC38A3, SERPINA4 (sc-type)

③ extravillous trophoblast

○ (+) AC022596.6, GKN1, CILP2, LINC00330, PDE6H, PRG2, RP11-872D17.8, HLA-G, ASCL2, NOTUM, AC006262.5, DAW1, NOG, TAC3, RP11-420L9.4 (sc-type)

④ trophoblast giant cell

○ (+) CCK, CTA-833B7.2, PSG1, CGB, CSH2, PSG6, KISS1, INHBA, GH2, PSG9, CRH, PSG8, RP11-76E12.1, PSG4, TREML3P (sc-type)

⑤ smooth muscle cell

○ (+) RP11-162G9.1, FAM162B, WNT3A, AFF2, CDH19, SCN11A, GPR20, COX4I2, AGTR1, ADAMTS20, RP11-123O22.1, HIGD1B, AC020571.3, COLEC10, KCNK17 (sc-type)

⑥ IGFBP1_DKK1 positive cell

○ (+) RP3-404K8.2, RP11-486P11.1, FOXL2, WT1, RP11-171A24.3, SCARA5, LRRN4CL, S100A3, WT1-AS, PRL, WNT4, AC012065.7, APOD, BRINP2, RORB (sc-type)

⑦ stromal cell

○ (+) AP006285.6, AC002451.1, RP11-99L13.2, RP1-79C4.4, MMP23B, RP11-248N22.2, LA16c-380H5.4, MIR218-1, C8orf87, SNORD113, RP11-74M11.2, HSD3BP2, AP001605.4, LINC00314, AC007394.3 (sc-type)

⑧ syncytiotrophoblasts and villous cytotrophoblast

○ (+) CTD-2050E21.1, POTEKP, RP11-344B2.3, RP11-366M4.3, RP11-2A4.4, RP11-483F11.7, FTLP14, RP11-718G2.5, RP11-18D7.3, CLCA2, KB-1440D3.13, CTBP2P8, RP11-359P18.1, HSPD1P6, AC124861.1 (sc-type)

⑨ megakaryocyte

○ (+) EGF, TUBB1, PPBP, ITGA2B, RP11-930O11.1, RP11-152K4.2, LINC00989, PF4, C6orf25, LINC00534, PKHD1L1, NRGN, DNM3, RP11-466L17.1, RP11-142C4.6 (sc-type)

⒄ tissue 16. spleen stroma

① AFP_ALB positive cell

○ (+) SERPINA6, PLG, AMBP, SERPINC1, BHMT2, LBP, PRAP1, APOB, SERPINA1, FGB, VTN, SLC2A2, FGG, MT1G, ITIH1 (sc-type)

② stromal cell

○ (+) CTD-2270F17.1, ENPP7P4, AC105053.3, RP11-388K12.1, SCTR, KBTBD11-OT1, ADRA1B, NPM1P10, NPY5R, TPH2, CTC-535M15.2, MIR143HG, KLHL29, AC023481.1, CADPS (sc-type)

③ STC2_TLX1 positive cell

○ (+) CAMK2N2, CLVS2, RP11-384O8.1, FBXL16, GABRG2, HRK, EBF3, TRH, AC018730.1, CTD-3193O13.9, CPLX2, ATP1A3, TMEM119, IFI27L2, PET117 (sc-type)

④ megakaryocyte

○ (+) RAB27B, RP11-556I14.2, EGF, GP6, RP11-930O11.1, LINC00989, SELP, GP1BA, HPSE, RP11-152K4.2, LINC00504, MMRN1, ITGB3, ELOVL7, LY6G6F (sc-type)

⒅ tissue 17. stomach stroma

① neuroendocrine cell

○ (+) SLC18A1, GHRL, GAST, FEV, NKX2-2, CRYBA2, MBOAT4, CDK5R2, RFX6, HAP1, RP11-82C23.2, RBPJL, PTF1A, PAX6, CACNA1A (sc-type)

② parietal and chief cell

○ (+) RP11-467I20.6, ETNPPL, ATP4B, FGB, FGA, SIGLEC11, FRMD1, TRIM50, ALB, ATP4A, ANGPTL3, MFSD4, APOBEC2, CKM, PAQR5 (sc-type)

③ MUC13_DMBT1 positive cell

○ (+) ISX, GUCA2B, ENPP7, MIR194-2, BTNL3, TM4SF20, SI, SLC17A4, ALDOB, CDX1, DMBT1, CHP2, KRT20, SLC5A12, ADRA2A (sc-type)

④ goblet cell

○ (+) UGT2B15, IL17C, GKN2, SLC22A8, CXCL5, CSF3, TFF2, A4GNT, FBP2, FGF20, MUC6, GKN1, CXCL1, MUC5AC, CA9 (sc-type)

⑤ stromal cell

○ (+) AC002511.2, PTGER1, OSR2, AC003090.1, ACTG2, INHBA, HSPB6, AC131025.8, SHISA3, DPT, TRPA1, ACTA2, TWIST2, CXCL14, GLIS1 (sc-type)

⑥ ENS neuron

○ (+) PRPH, STMN2, ATP1A3, KCNIP4, NKAIN1, INA, GAP43, ATCAY, CNGB1, TCEAL5, STAC, DCX, RP11-457K10.1, FAM163A, CNTN5 (sc-type)

⑦ ENS glia

○ (+) SOX10, MPZ, ATP1A2, BAI1, PLP1, CDH19, COL20A1, ELOVL2, NOV, PRIMA1, RP11-308N19.1, SLC35F1, LGI4, VGLL3, EGFLAM (sc-type)

⑧ PDE1C_ACSM3 positive cell

○ (+) RP11-690G19.4, ACSM3, C1orf95, KCNE4, PDE1C, PSEN2, ERBB4, ATP6V0A4, TFCP2L1, WNK3, GABRB2, ADARB2, AMACR, SHISA2, NOX4 (sc-type)

⒆ tissue 18. thymus stroma (thyroid stroma)

① stromal cell

○ (+) PLAC9, LOX, MGP, COL1A2, COL5A3, COL1A1, ASPN, FGF18, MMP2, ISLR, DCN, SFRP2, COL3A1, SCARA5, COL6A6 (sc-type)

② thymocyte

○ (+) RP11-104L21.3, BEST3, HKDC1, KLRC4-KLRK1, RP11-305P22.9, LTA, TMSB15B, RP11-739G5.1, UBASH3A, PLK4, FBXO41, LIN28B, SKA3, CD40LG, AC002454.1 (sc-type)

○ (+) C1orf228, VIPR2, SLAMF1, CCR9, CHRM3-AS2, SMC4, LEF1, ARRDC2, BACH2, SCML1 (Tabula Sapiens)

③ follicular cell

⒇ tissue 19. bladder stroma

① fibroblast

② myofibroblast cell

③ pericyte

④ smooth muscle cell

⒇ tissue 20. reproductive system (e.g., prostate)

① decidual cell

○ (+) XCL1, IGFBP1, XCL2, CTSW, IL32, TRDC, KLRC1, PRL, AREG (PanglaoDB)

② germ cell

○ (+) DDX4, PRM1, ODF2, CRISP2, TCP11, PHF7, SPINK2, TSACC, PGK2, GTSF1, LELP1, MAEL, CCDC91, COX8C, FAM71E1, SPATA33, HMGB4, ROPN1L, TNP1, SMCP, LDHC, PRM2, DKKL1, MLF1, NR6A1, RSBN1L, DYNLT1, MRPL14, CREM (PanglaoDB)

③ granulosa cell

○ (+) AMH, INHA, TNNI3 (PanglaoDB)

④ Leydig cell

○ (+) INHA, DHCR7, CALB2, CYP17A1, CYP11A1, INSL3, LHCGR, STAR, PTGDS, HSD17B3, SMOC2, GJA1 (PanglaoDB)

⑤ Luteal cell

⑥ peritubular myoid cell

○ (+) SAT2, GSTM3, RNASE1, OSR2, MYL9 (PanglaoDB)

⑦ Sertoli cell

⑧ spermatocyte

○ (+) PRM1, PRM2, TNP1 (PanglaoDB)

⑨ spermatozoa

6. Type 5. others

⑴ embryo

① class 1. epiblast cell

② class 2. hemangioblast

③ class 3. trophoblast cell

④ class 4. trophoblast progenitor cell

⑤ class 5. trophoblast stem cell

⑥ class 6. embryonic stem cell (zygote)

⑵ state 1. EMT(epithelial-to-mesenchymal transition): Main mechanism of metastasis

① (+) GATA3, TWIST2, SNAI2

② (-) DEFB4A, LCN2

⑶ state 2. MET(mesenchymal-to-epithelial transition)

⑷ state 3. EndMT(endothelial-to-mesenchymal transition)

⑸ state 4. MMT(mesothelial-to-mesenchymal transition)

⑹ state 5. MMT(monocyte-to-myofibroblast trans-differentiation)

Input : 2020.02.06 00:43

Revised : 2023.08.27 00:49

1846

Cell Type Marker Genes

1. Overview

2. Type 1. epithelial cell

3. Type 2. endothelial cell

4. Type 3. immune cell

5. Type 4. stromal cell

6. Type 5. others

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